TY - JOUR
T1 - Cell competition in development, homeostasis and cancer
AU - van Neerven, Sanne M.
AU - Vermeulen, Louis
N1 - Funding Information: S.M.v.N. is supported by ZonMw (Rubicon 452021320) and an EMBO Postdoctoral Fellowship (122-2022, non-stipendiary). This work is supported by Oncode Institute, the New York Stem Cell Foundation and grants from the European Research Council (ERG-CoG 101045612 - NIMICRY) and ZonMw (Vici 09-15018-21-10029) to L.V. L.V. is a New York Stem Cell Foundation–Robertson Stem Cell Investigator. The authors thank the members of the Laboratory for Experimental Oncology and Radiobiology for insightful discussions and comments on a draft of this work. Publisher Copyright: © 2022, Springer Nature Limited.
PY - 2022
Y1 - 2022
N2 - Organ development and homeostasis involve dynamic interactions between individual cells that collectively regulate tissue architecture and function. To ensure the highest tissue fidelity, equally fit cell populations are continuously renewed by stochastic replacement events, while cells perceived as less fit are actively removed by their fitter counterparts. This renewal is mediated by surveillance mechanisms that are collectively known as cell competition. Recent studies have revealed that cell competition has roles in most, if not all, developing and adult tissues. They have also established that cell competition functions both as a tumour-suppressive mechanism and as a tumour-promoting mechanism, thereby critically influencing cancer initiation and development. This Review discusses the latest insights into the mechanisms of cell competition and its different roles during embryonic development, homeostasis and cancer.
AB - Organ development and homeostasis involve dynamic interactions between individual cells that collectively regulate tissue architecture and function. To ensure the highest tissue fidelity, equally fit cell populations are continuously renewed by stochastic replacement events, while cells perceived as less fit are actively removed by their fitter counterparts. This renewal is mediated by surveillance mechanisms that are collectively known as cell competition. Recent studies have revealed that cell competition has roles in most, if not all, developing and adult tissues. They have also established that cell competition functions both as a tumour-suppressive mechanism and as a tumour-promoting mechanism, thereby critically influencing cancer initiation and development. This Review discusses the latest insights into the mechanisms of cell competition and its different roles during embryonic development, homeostasis and cancer.
UR - http://www.scopus.com/inward/record.url?scp=85139063977&partnerID=8YFLogxK
U2 - https://doi.org/10.1038/s41580-022-00538-y
DO - https://doi.org/10.1038/s41580-022-00538-y
M3 - Review article
C2 - 36175766
SN - 1471-0072
JO - Nature reviews. Molecular cell biology
JF - Nature reviews. Molecular cell biology
ER -