TY - JOUR
T1 - Cellular Effects of Helium in Different Organs
AU - Oei, Gezina T. M. L.
AU - Weber, Nina C.
AU - Hollmann, Markus W.
AU - Preckel, Benedikt
PY - 2010
Y1 - 2010
N2 - Experimental research in cardiac and neuronal tissue has shown that besides volatile anesthetics and xenon, the non-anesthetic noble gas helium also reduces ischemia-reperfusion damage. Even though the distinct mechanisms of helium-induced organ protection are not completely unraveled, several signaling pathways have been identified. Beside the protective effects on heart and brain that are mainly obtained by different pre- and postconditioning protocols, helium also exerts effects in the lungs, the immune system, and the blood vessels. Obviously, this noble gas is biochemically not inert and exerts biologic effects, although until today the question remains open on how these changes are mediated. Because of its favorable characteristics and the lack of hemodynamic side effects, helium is suitable for use also in critically ill patients. This review covers the cellular effects of helium, which may lead to new clinical strategies of tissue salvage in ischemia-reperfusion situations, both within and outside the perioperative setting
AB - Experimental research in cardiac and neuronal tissue has shown that besides volatile anesthetics and xenon, the non-anesthetic noble gas helium also reduces ischemia-reperfusion damage. Even though the distinct mechanisms of helium-induced organ protection are not completely unraveled, several signaling pathways have been identified. Beside the protective effects on heart and brain that are mainly obtained by different pre- and postconditioning protocols, helium also exerts effects in the lungs, the immune system, and the blood vessels. Obviously, this noble gas is biochemically not inert and exerts biologic effects, although until today the question remains open on how these changes are mediated. Because of its favorable characteristics and the lack of hemodynamic side effects, helium is suitable for use also in critically ill patients. This review covers the cellular effects of helium, which may lead to new clinical strategies of tissue salvage in ischemia-reperfusion situations, both within and outside the perioperative setting
U2 - https://doi.org/10.1097/ALN.0b013e3181d9cb5e
DO - https://doi.org/10.1097/ALN.0b013e3181d9cb5e
M3 - Review article
C2 - 20460992
SN - 0003-3022
VL - 112
SP - 1503
EP - 1510
JO - Anesthesiology
JF - Anesthesiology
IS - 6
ER -