Censoring exosomal crosstalk in osteoarthritis

DM Pegtel, SR Baglio, Ingrid Meulenbelt

Research output: Contribution to journalArticleAcademicpeer-review


Using mouse models of osteoarthritis (OA), a new study finds that osteoclasts secrete exosomes that deliver miRNAs to chondrocytes, leading to an increase in metalloproteinase activity in cartilage. A bone-specific inhibitor of exosome production can halt this process, hinting at a new therapeutic strategy for patients with OA.
Original languageEnglish
Article number1
Pages (from-to)332
Number of pages334
JournalNature Aging
Publication statusPublished - 15 Apr 2021

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