Cerebral amyloid burden is associated with white matter hyperintensity location in specific posterior white matter regions

TRACE-VCI study group

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34 Citations (Scopus)


White matter hyperintensities (WMHs) are a common manifestation of cerebral small vessel disease. WMHs are also frequently observed in patients with familial and sporadic Alzheimer's disease, often with a particular posterior predominance. Whether amyloid and tau pathologies are linked to WMH occurrence is still debated. We examined whether cerebral amyloid and tau burden, reflected in cerebrospinal fluid amyloid-beta 1-42 (Aβ-42) and phosphorylated tau (p-tau), are related to WMH location in a cohort of 517 memory clinic patients. Two lesion mapping techniques were performed: voxel-based analyses and region of interest-based linear regression. Voxelwise associations were found between lower Aβ-42 and parieto-occipital periventricular WMHs. Regression analyses demonstrated that lower Aβ-42 correlated with larger WMH volumes in the splenium of the corpus callosum and posterior thalamic radiation, also after controlling for markers of vascular disease. P-tau was not consistently related to WMH occurrence. Our findings indicate that cerebral amyloid burden is associated with WMHs located in specific posterior white matter regions, possibly reflecting region-specific effects of amyloid pathology on the white matter.
Original languageEnglish
Pages (from-to)225-234
Number of pages10
JournalNeurobiology of aging
Publication statusPublished - 1 Dec 2019


  • Alzheimer's disease
  • Amyloid-beta
  • Cerebrospinal fluid
  • Lesion mapping
  • Magnetic resonance imaging
  • Tau
  • White matter hyperintensities

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