Cerebral blood flow and predictors of white matter lesions in adults with Tetralogy of Fallot

Yaqiong Chai, Jieshen Chen, Cristina Galarza, Maaykea. Sluman, Botian Xu, Chau Q. Vu, Edo Richard, Barbara Mulder, Benita Tamrazi, Natasha Lepore, Henri J. M. M. Mutsaerts, John C. Wood

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

4 Citations (Scopus)


Long-term outcomes for Tetralogy of Fallot (TOF) have improved dramatically in recent years, but survivors are still afflicted by cerebral damage. In this paper, we characterized the prevalence and predictors of cerebral silent infarction (SCI) and their relationship to cerebral blood flow (CBF) in 46 adult TOF patients. We calculated both whole brain and regional CBF using 2D arterial spin labeling (ASL) images, and investigated the spatial overlap between voxel-wise CBF values and white matter hyperintensities (WMHs) identified from T2-FLAIR images. SCIs were found in 83% of subjects and were predicted by the year of the patient's first cardiac surgery and patient's age at scanning (combined r2 0.44). CBF was not different in brain regions prone to stroke compared with healthy white matter.
Original languageEnglish
Title of host publication2018 IEEE 15th International Symposium on Biomedical Imaging, ISBI 2018
PublisherIEEE Computer Society
ISBN (Electronic)9781538636367
Publication statusPublished - 2018
Event15th IEEE International Symposium on Biomedical Imaging, ISBI 2018 - Washington, United States
Duration: 4 Apr 20187 Apr 2018

Publication series

NameProceedings - International Symposium on Biomedical Imaging


Conference15th IEEE International Symposium on Biomedical Imaging, ISBI 2018
Country/TerritoryUnited States

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