Cerebral blood flow and predictors of white matter lesions in adults with Tetralogy of Fallot

Yaqiong Chai; Jieshen Chen; Cristina Galarza; Maaykea. Sluman; Botian Xu; Chau Q. Vu; Edo Richard; Barbara Mulder; Benita Tamrazi; Natasha Lepore; Henri J. M. M. Mutsaerts; John C. Wood

doi:https://doi.org/10.1109/ISBI.2018.8363812

Cerebral blood flow and predictors of white matter lesions in adults with Tetralogy of Fallot

Yaqiong Chai, Jieshen Chen, Cristina Galarza, Maaykea. Sluman, Botian Xu, Chau Q. Vu, Edo Richard, Barbara Mulder, Benita Tamrazi, Natasha Lepore, Henri J. M. M. Mutsaerts, John C. Wood

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

4 Citations (Scopus)

Abstract

Long-term outcomes for Tetralogy of Fallot (TOF) have improved dramatically in recent years, but survivors are still afflicted by cerebral damage. In this paper, we characterized the prevalence and predictors of cerebral silent infarction (SCI) and their relationship to cerebral blood flow (CBF) in 46 adult TOF patients. We calculated both whole brain and regional CBF using 2D arterial spin labeling (ASL) images, and investigated the spatial overlap between voxel-wise CBF values and white matter hyperintensities (WMHs) identified from T2-FLAIR images. SCIs were found in 83% of subjects and were predicted by the year of the patient's first cardiac surgery and patient's age at scanning (combined r2 0.44). CBF was not different in brain regions prone to stroke compared with healthy white matter.

Original language	English
Title of host publication	2018 IEEE 15th International Symposium on Biomedical Imaging, ISBI 2018
Publisher	IEEE Computer Society
Pages	1309-1312
Volume	2018-April
ISBN (Electronic)	9781538636367
DOIs	https://doi.org/10.1109/ISBI.2018.8363812
Publication status	Published - 2018
Event	15th IEEE International Symposium on Biomedical Imaging, ISBI 2018 - Washington, United States Duration: 4 Apr 2018 → 7 Apr 2018

Publication series

Name	Proceedings - International Symposium on Biomedical Imaging

Conference

Conference	15th IEEE International Symposium on Biomedical Imaging, ISBI 2018
Country/Territory	United States
City	Washington
Period	4/04/2018 → 7/04/2018

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https://doi.org/10.1109/ISBI.2018.8363812

Cite this

Chai, Y., Chen, J., Galarza, C., Sluman, M., Xu, B., Vu, C. Q., Richard, E., Mulder, B., Tamrazi, B., Lepore, N., Mutsaerts, H. J. M. M., & Wood, J. C. (2018). Cerebral blood flow and predictors of white matter lesions in adults with Tetralogy of Fallot. In 2018 IEEE 15th International Symposium on Biomedical Imaging, ISBI 2018 (Vol. 2018-April, pp. 1309-1312). (Proceedings - International Symposium on Biomedical Imaging). IEEE Computer Society. https://doi.org/10.1109/ISBI.2018.8363812

@inproceedings{cd16c49be8d34160bca24a7d5163583e,

title = "Cerebral blood flow and predictors of white matter lesions in adults with Tetralogy of Fallot",

abstract = "Long-term outcomes for Tetralogy of Fallot (TOF) have improved dramatically in recent years, but survivors are still afflicted by cerebral damage. In this paper, we characterized the prevalence and predictors of cerebral silent infarction (SCI) and their relationship to cerebral blood flow (CBF) in 46 adult TOF patients. We calculated both whole brain and regional CBF using 2D arterial spin labeling (ASL) images, and investigated the spatial overlap between voxel-wise CBF values and white matter hyperintensities (WMHs) identified from T2-FLAIR images. SCIs were found in 83% of subjects and were predicted by the year of the patient's first cardiac surgery and patient's age at scanning (combined r2 0.44). CBF was not different in brain regions prone to stroke compared with healthy white matter.",

author = "Yaqiong Chai and Jieshen Chen and Cristina Galarza and Maaykea. Sluman and Botian Xu and Vu, {Chau Q.} and Edo Richard and Barbara Mulder and Benita Tamrazi and Natasha Lepore and Mutsaerts, {Henri J. M. M.} and Wood, {John C.}",

year = "2018",

doi = "https://doi.org/10.1109/ISBI.2018.8363812",

language = "English",

volume = "2018-April",

series = "Proceedings - International Symposium on Biomedical Imaging",

publisher = "IEEE Computer Society",

pages = "1309--1312",

booktitle = "2018 IEEE 15th International Symposium on Biomedical Imaging, ISBI 2018",

note = "15th IEEE International Symposium on Biomedical Imaging, ISBI 2018 ; Conference date: 04-04-2018 Through 07-04-2018",

}

Chai, Y, Chen, J, Galarza, C, Sluman, M, Xu, B, Vu, CQ, Richard, E , Mulder, B, Tamrazi, B, Lepore, N, Mutsaerts, HJMM & Wood, JC 2018, Cerebral blood flow and predictors of white matter lesions in adults with Tetralogy of Fallot. in 2018 IEEE 15th International Symposium on Biomedical Imaging, ISBI 2018. vol. 2018-April, Proceedings - International Symposium on Biomedical Imaging, IEEE Computer Society, pp. 1309-1312, 15th IEEE International Symposium on Biomedical Imaging, ISBI 2018, Washington, United States, 4/04/2018. https://doi.org/10.1109/ISBI.2018.8363812

Cerebral blood flow and predictors of white matter lesions in adults with Tetralogy of Fallot. / Chai, Yaqiong; Chen, Jieshen; Galarza, Cristina et al.
2018 IEEE 15th International Symposium on Biomedical Imaging, ISBI 2018. Vol. 2018-April IEEE Computer Society, 2018. p. 1309-1312 (Proceedings - International Symposium on Biomedical Imaging).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

TY - GEN

T1 - Cerebral blood flow and predictors of white matter lesions in adults with Tetralogy of Fallot

AU - Chai, Yaqiong

AU - Chen, Jieshen

AU - Galarza, Cristina

AU - Sluman, Maaykea.

AU - Xu, Botian

AU - Vu, Chau Q.

AU - Richard, Edo

AU - Mulder, Barbara

AU - Tamrazi, Benita

AU - Lepore, Natasha

AU - Mutsaerts, Henri J. M. M.

AU - Wood, John C.

PY - 2018

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N2 - Long-term outcomes for Tetralogy of Fallot (TOF) have improved dramatically in recent years, but survivors are still afflicted by cerebral damage. In this paper, we characterized the prevalence and predictors of cerebral silent infarction (SCI) and their relationship to cerebral blood flow (CBF) in 46 adult TOF patients. We calculated both whole brain and regional CBF using 2D arterial spin labeling (ASL) images, and investigated the spatial overlap between voxel-wise CBF values and white matter hyperintensities (WMHs) identified from T2-FLAIR images. SCIs were found in 83% of subjects and were predicted by the year of the patient's first cardiac surgery and patient's age at scanning (combined r2 0.44). CBF was not different in brain regions prone to stroke compared with healthy white matter.

AB - Long-term outcomes for Tetralogy of Fallot (TOF) have improved dramatically in recent years, but survivors are still afflicted by cerebral damage. In this paper, we characterized the prevalence and predictors of cerebral silent infarction (SCI) and their relationship to cerebral blood flow (CBF) in 46 adult TOF patients. We calculated both whole brain and regional CBF using 2D arterial spin labeling (ASL) images, and investigated the spatial overlap between voxel-wise CBF values and white matter hyperintensities (WMHs) identified from T2-FLAIR images. SCIs were found in 83% of subjects and were predicted by the year of the patient's first cardiac surgery and patient's age at scanning (combined r2 0.44). CBF was not different in brain regions prone to stroke compared with healthy white matter.

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VL - 2018-April

T3 - Proceedings - International Symposium on Biomedical Imaging

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BT - 2018 IEEE 15th International Symposium on Biomedical Imaging, ISBI 2018

PB - IEEE Computer Society

T2 - 15th IEEE International Symposium on Biomedical Imaging, ISBI 2018

Y2 - 4 April 2018 through 7 April 2018

ER -

Chai Y, Chen J, Galarza C, Sluman M, Xu B, Vu CQ et al. Cerebral blood flow and predictors of white matter lesions in adults with Tetralogy of Fallot. In 2018 IEEE 15th International Symposium on Biomedical Imaging, ISBI 2018. Vol. 2018-April. IEEE Computer Society. 2018. p. 1309-1312. (Proceedings - International Symposium on Biomedical Imaging). doi: https://doi.org/10.1109/ISBI.2018.8363812

Cerebral blood flow and predictors of white matter lesions in adults with Tetralogy of Fallot

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