TY - JOUR
T1 - Cerebral hemodynamics during sustained intraoperative hypotension
AU - Kho, Eline
AU - Sperna Weiland, Nicolaas H.
AU - Vlaar, Alexander P. J.
AU - Veelo, Denise P.
AU - van der Ster, Björn J. P.
AU - Corsmit, Oskar T.
AU - Koolbergen, Dave R.
AU - Dilai, José
AU - Immink, Rogier V.
N1 - Publisher Copyright: Copyright © 2022 the American Physiological Society.
PY - 2022/6/1
Y1 - 2022/6/1
N2 - Static cerebral autoregulation (CA) maintains cerebral blood flow (CBF) relatively constant above a mean arterial blood pressure (BPmean) of 60–65 mmHg. Below this lower limit of CA (LLCA), CBF declines along with BPmean. Data are lacking in describing how CA reacts to sustained hypotension since hypotension is usually avoided. In this study, we took advantage of a procedure requiring sustained hypotension. We assessed static CA for LLCA determination, and a more continuous CA, which counters short-term blood pressure variations. With these data, we analyzed CA during longstanding hypotension. Continuous arterial blood pressure and middle cerebral artery blood flow velocity (MCAVmean) were monitored in 23 patients that required deep intraoperative hypotension. The LLCA was determined for every patient, and BPmean below this LLCA was classified as the patient-specific hypotension. With the mean flow index (Mxa), continuous CA (Mxa-CA) was quantified. Mxa was calculated and averaged after induction of general anesthesia (baseline), every 15 min during, and 15 min after 1 h of hypotension. Functioning CA was defined as Mxa < 0.4. Data are expressed as median (25th–75th percentile). The LLCA was located at 56 (47–74) mmHg. At baseline, Mxa was 0.21 (0.14–0.32) and 0.61 (0.48–0.78) during hypotension (P < 0.01), with no appreciable change over time, n = 12. After blood pressure restoration, Mxa improved, 0.25 (0.06–0.35, n = 9). MxaCA became and remained disturbed during the 1 h of hypotension, and improved after blood pressure restoration. This completely reversible situation suggests no ischemic hyperemia occurs and renders an adaptation mechanism during sustained hypotension unlikely. NEW & NOTEWORTHY Intraoperative hypotension is normally avoided by anesthesiologists. However, for the Personalized External Aortic Root Support (PEARS) procedure, deep-induced hypotension is an essential requirement for the surgeon to be able to manipulate the aortic root. In this procedure, blood pressure and middle cerebral artery blood flow velocity were monitored. In this study, we assessed cerebral autoregulation during sustained hypotension, to give an insight into its behavior during hypotension.
AB - Static cerebral autoregulation (CA) maintains cerebral blood flow (CBF) relatively constant above a mean arterial blood pressure (BPmean) of 60–65 mmHg. Below this lower limit of CA (LLCA), CBF declines along with BPmean. Data are lacking in describing how CA reacts to sustained hypotension since hypotension is usually avoided. In this study, we took advantage of a procedure requiring sustained hypotension. We assessed static CA for LLCA determination, and a more continuous CA, which counters short-term blood pressure variations. With these data, we analyzed CA during longstanding hypotension. Continuous arterial blood pressure and middle cerebral artery blood flow velocity (MCAVmean) were monitored in 23 patients that required deep intraoperative hypotension. The LLCA was determined for every patient, and BPmean below this LLCA was classified as the patient-specific hypotension. With the mean flow index (Mxa), continuous CA (Mxa-CA) was quantified. Mxa was calculated and averaged after induction of general anesthesia (baseline), every 15 min during, and 15 min after 1 h of hypotension. Functioning CA was defined as Mxa < 0.4. Data are expressed as median (25th–75th percentile). The LLCA was located at 56 (47–74) mmHg. At baseline, Mxa was 0.21 (0.14–0.32) and 0.61 (0.48–0.78) during hypotension (P < 0.01), with no appreciable change over time, n = 12. After blood pressure restoration, Mxa improved, 0.25 (0.06–0.35, n = 9). MxaCA became and remained disturbed during the 1 h of hypotension, and improved after blood pressure restoration. This completely reversible situation suggests no ischemic hyperemia occurs and renders an adaptation mechanism during sustained hypotension unlikely. NEW & NOTEWORTHY Intraoperative hypotension is normally avoided by anesthesiologists. However, for the Personalized External Aortic Root Support (PEARS) procedure, deep-induced hypotension is an essential requirement for the surgeon to be able to manipulate the aortic root. In this procedure, blood pressure and middle cerebral artery blood flow velocity were monitored. In this study, we assessed cerebral autoregulation during sustained hypotension, to give an insight into its behavior during hypotension.
KW - cerebral autoregulation
KW - cerebral autoregulation efficacy
KW - cerebral blood flow velocity
KW - cerebrovascular circulation
KW - hypotension
UR - http://www.scopus.com/inward/record.url?scp=85131904005&partnerID=8YFLogxK
U2 - https://doi.org/10.1152/japplphysiol.00050.2022
DO - https://doi.org/10.1152/japplphysiol.00050.2022
M3 - Article
C2 - 35511723
SN - 8750-7587
VL - 132
SP - 1560
EP - 1568
JO - Journal of applied physiology (Bethesda, Md.
JF - Journal of applied physiology (Bethesda, Md.
IS - 6
ER -