@article{9195fdcc6b91494699ed90bacab64dad,
title = "Cerebral perfusion in untreated, controlled, and uncontrolled hypertension",
abstract = "This study evaluated the association between systemic arterial blood pressure and cerebral perfusion in 740 participants of the UK's largest tri-ethnic study with measurements of cerebral blood flow (CBF) performed using arterial spin labelling MRI. A significant negative correlation between blood pressure, age and CBF was observed across the patient cohort. The lowest CBF values were recorded in the group of patients with hypertension that were prescribed with anti-hypertensive drugs, but uncontrolled on medication. These findings confirm that hypertension is associated with reduced cerebral perfusion and highlight the importance of blood pressure control for the benefit of maintaining brain blood flow.",
keywords = "Cerebral blood flow, MRI, brain, hypertension, perfusion",
author = "Christie, {Isabel N.} and Rowan Windsor and Mutsaerts, {Henk J. MM} and Therese Tillin and Sudre, {Carole H.} and Hughes, {Alun D.} and Xavier Golay and Gourine, {Alexander V.} and Hosford, {Patrick S.}",
note = "Funding Information: The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by The Wellcome Trust (AVG; refs: 200893 and 223057) and the British Heart Foundation (AVG; ref: RG/19/5/34463). AVG was supported by a Wellcome Senior Research Fellowship (ref: 200893). HM is supported by the Dutch Heart Foundation (03-004-2020-T049), by the Eurostars-2 joint programme with co-funding from the European Union Horizon 2020 research and innovation programme (ASPIRE E!113701), provided by the Netherlands Enterprise Agency (RvO), and by the EU Joint Program for Neurodegenerative Disease Research, provided by the Netherlands Organisation for health Research and Development and Alzheimer Nederland (DEBBIE JPND2020-568-106). Publisher Copyright: {\textcopyright} The Author(s) 2022.",
year = "2022",
month = dec,
doi = "https://doi.org/10.1177/0271678X221124644",
language = "English",
volume = "42",
pages = "2188--2190",
journal = "Journal of cerebral blood flow and metabolism",
issn = "0271-678X",
publisher = "Nature Publishing Group",
number = "12",
}