Cerebral proton magnetic resonance spectroscopy of a patient with giant axonal neuropathy

Knut Brockmann, Petra J.W. Pouwels, Peter Dechent, Kevin M. Flanigan, Jens Frahm, Folker Hanefeld

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2 Citations (Scopus)


Magnetic resonance imaging of a girl with giant axonal neuropathy revealed a progressive white matter disease. In close agreement with histopathological features reported previously, localized proton magnetic resonance spectroscopy at 9 and 12 years of age indicated a specific damage or loss of axons (reduced N-acetylaspartate and N-acetylaspartylglutamate) accompanied by acute demyelination (elevated choline-containing compounds, myo-inositol, and lactate) in white matter as well as a generalized proliferation of glial cells (elevated choline-containing compounds and myo-inositol) in both gray and white matter.

Original languageEnglish
Pages (from-to)45-50
Number of pages6
JournalBrain and Development
Issue number1
Publication statusPublished - 1 Jan 2003
Externally publishedYes


  • Demyelination
  • Giant axonal neuropathy
  • Leukoencephalopathy
  • Magnetic resonance spectroscopy

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