Cerebral venous thrombosis: Epidemiology, clinical course, and outcome

Research output: PhD ThesisPhD-Thesis - Research and graduation internal


The first part of this thesis focuses on the epidemiology of CVT. Chapter 2 describes a cross-sectional study that investigates the incidence of CVT among hospitalized adult patients located in two provinces in The Netherlands. Chapter 3 is a systematic review of the literature regarding the shift in sex ratio over time among patients with CVT. Chapter 4 describes a case-control study in which we investigated the association between obesity and CVT. In chapter 5, we report the results of a systematic analysis of the literature on the decline in mortality over time in CVT.
In the second part of this thesis, we highlight the clinical course and outcome of CVT. Chapter 6 describes a retrospective study that reports the clinical course of adults with CVT during treatment for acute lymphoblastic leukemia. The relevance of early symptoms and treatments are explored. Chapter 7 describes a cohort study that aimed to assess the association between hyperglycemia and clinical outcome in CVT. Chapter 8 is a post hoc-analysis of the International Study on Cerebral Venous and dural sinus Thrombosis (ISCVT) study, in which we examined CVT associated with an infection of the head or neck. Chapter 9 describes the frequency, pathophysiology and clinical manifestations of hydrocephalus in patients with CVT, and discusses how hydrocephalus may contribute to poor clinical outcome in these patients. Chapter 10 describes a prospective cohort study on the efficacy of decompressive hemicraniectomy for severe cases of CVT with impending herniation. Finally, chapter 11 summarizes the results and conclusions presented in this thesis and addresses future directions for research on CVT.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • Stam, J., Supervisor
  • Coutinho, Jonathan, Co-supervisor
Award date28 Oct 2016
Print ISBNs9789492303073
Publication statusPublished - 2016

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