European Neuroendocrine Tumor Society (ENETS) 2023 guidance paper for colorectal neuroendocrine tumours

Anja Rinke; Valentina Ambrosini; Clarisse Dromain; Rocio Garcia-Carbonero; Amyn Haji; Anna Koumarianou; Els Nieveen van Dijkum; Dermot O'Toole; Guido Rindi; Jean-Yves Scoazec; John Ramage

doi:https://doi.org/10.1111/jne.13309

European Neuroendocrine Tumor Society (ENETS) 2023 guidance paper for colorectal neuroendocrine tumours

Anja Rinke, Valentina Ambrosini, Clarisse Dromain, Rocio Garcia-Carbonero, Amyn Haji, Anna Koumarianou, Els Nieveen van Dijkum, Dermot O'Toole, Guido Rindi, Jean-Yves Scoazec, John Ramage

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Abstract

This ENETS guidance paper, developed by a multidisciplinary working group, provides an update on the previous colorectal guidance paper in a different format. Guided by key clinical questions practical advice on the diagnosis and management of neuroendocrine tumours (NET) of the caecum, colon, and rectum is provided. Although covered in one guidance paper colorectal NET comprises a heterogeneous group of neoplasms. The most common rectal NET are often small G1 tumours that can be treated by adequate endoscopic resection techniques. Evidence from prospective clinical trials on the treatment of metastatic colorectal NET is limited and discussion of patients in experienced multidisciplinary tumour boards strongly recommended. Neuroendocrine carcinomas (NEC) and mixed neuroendocrine non-neuroendocrine neoplasms (MiNEN) are discussed in a separate guidance paper.

Original language	English
Article number	e13309
Journal	Journal of neuroendocrinology
Volume	35
Issue number	6
Early online date	2023
DOIs	https://doi.org/10.1111/jne.13309
Publication status	Published - Jun 2023

Keywords

colorectal
endoscopic treatment
guideline
neuroendocrine tumour
rectal carcinoid

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https://doi.org/10.1111/jne.13309

Cite this

@article{cfa405ea828a43a783a3b9ee228dc0f3,

title = "European Neuroendocrine Tumor Society (ENETS) 2023 guidance paper for colorectal neuroendocrine tumours",

abstract = "This ENETS guidance paper, developed by a multidisciplinary working group, provides an update on the previous colorectal guidance paper in a different format. Guided by key clinical questions practical advice on the diagnosis and management of neuroendocrine tumours (NET) of the caecum, colon, and rectum is provided. Although covered in one guidance paper colorectal NET comprises a heterogeneous group of neoplasms. The most common rectal NET are often small G1 tumours that can be treated by adequate endoscopic resection techniques. Evidence from prospective clinical trials on the treatment of metastatic colorectal NET is limited and discussion of patients in experienced multidisciplinary tumour boards strongly recommended. Neuroendocrine carcinomas (NEC) and mixed neuroendocrine non-neuroendocrine neoplasms (MiNEN) are discussed in a separate guidance paper.",

keywords = "colorectal, endoscopic treatment, guideline, neuroendocrine tumour, rectal carcinoid",

author = "Anja Rinke and Valentina Ambrosini and Clarisse Dromain and Rocio Garcia-Carbonero and Amyn Haji and Anna Koumarianou and {van Dijkum}, {Els Nieveen} and Dermot O'Toole and Guido Rindi and Jean-Yves Scoazec and John Ramage",

note = "Funding Information: We thank the members of the ENETS office for their support. The authors of this ENETS guidance paper are grateful to the ENETS Advisory Board members for their useful suggestions and comments in a common effort to improve the quality of the present manuscript. Following colleagues were participants of the ENETS guidance paper consensus meeting 13 October 2022: Bartsch, D. K. (Department of Visceral-, Thoracic- and Vascular Surgery Philipps-University Marburg, Marburg, Germany); Begum N. (Department for General-, Visceral-, Thoracic- and Endocrine Surgery, Johannes-Wesling-Klinikum Minden, University Hospital of the Ruhr-University Bochum, Germany); Capdevila, J. (Medical Oncology Department, Gastrointestinal and Endocrine Unit, Vall d'Hebron University Hospital, Barcelona, Spain); Caplin, M. (Neuroendocrine Tumour Unit, ENETS Center of Excellence, Royal Free Hospital and University College London, London, United Kingdom); Casta{\~n}o, J. P. (Maimonides Biomedical Research Institute of C{\'o}rdoba (IMIBIC), Reina Sofia University Hospital, University of C{\'o}rdoba, C{\'o}rdoba, Spain); Couvelard, A. (Pathology Department, Bichat Hospital, AP-HP and Universit{\'e} Paris Cit{\'e}, Paris, France); Denecke T. (Universit{\"a}tsklinikum Leipzig, Klinik f{\"u}r Diagnostische und Interventionelle Radiologie, Leipzig, Germany); Deroose, C. M. (University Hospitals Leuven, Nuclear Medicine and KU Leuven, Department of Imaging and Pathology, Nuclear Medicine & Molecular Imaging, Leuven, Belgium); Fazio, N. (Division of Gastrointestinal Medical Oncology and Neuroendocrine Tumours, European Institute of Oncology (IEO), IRCCS, Milan, Italy); Hofland, J. (Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands); Kaltsas, G. (1st Propaedeutic Department of Internal Medicine, National and Kapodistrian University of Athens, Athens, Greece); Kjaer, A. (Department of Clinical Physiology and Nuclear Medicine & Cluster for Molecular Imaging, Copenhagen University Hospital – Rigshospitalet & Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark); Knigge, U. (Departments of Surgery and Clinical Endocrinology, ENETS Center of Excellence, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark); Kos-Kud{\l}a, B. (Department of Endocrinology and Neuroendocrine Tumours, Medical University of Silesia, Katowice, Poland); Panzuto, F. (Department of Medical-Surgical Sciences and Translational Medicine, Sapienza University of Rome / Digestive Disease Unit, Sant'Andrea University Hospital, ENETS Center of Excellence, Rome, Italy); Pavel, M. (Department of Medicine 1, Universit{\"a}tsklinikum Erlangen, Erlangen, Germany); Peeters M. (Antwerp University Hospital, Department of Oncology, Edegem, Belgium); Salazar R. (Institut Catal{\`a} d'Oncologia, Barcelona, Spain); Santos A. P. (Endocrinology Department, Endocrine Tumours Clinic, Precancerous Lesions and Early Cancer Management Group, RISE@CI-IPO (Health Research Network), Portuguese Oncology Institute of Porto (IPO Porto) / Porto Comprehensive Cancer Center (Porto.CCC), Porto, Portugal); Sorbye H. (Haukeland University Hospital, Dept. of Oncology, Bergen, Norway); Srirajaskanthan R. (Neuroendocrine Tumour Unit, Kings College Hospital / Department of Gastroenterology, Hambleden Wing, Kings College Hospital, London, United Kingdom); Sundin A. (Uppsala University, Surgical Sciences, Uppsala, Sweden); Tesselaar, M.E.T. (Department of Gastrointestinal Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands); Tiensuu Janson, E. (Department of Medical Sciences, Endocrine Oncology, Medical Faculty, Uppsala Universitet, Uppsala, Sweden); Toumpanakis, C. (Neuroendocrine Tumour Unit, ENETS Center of Excellence, Royal Free Hospital and University College London, London, United Kingdom); van Velthuysen, M. F. (Department of Pathology, Erasmus MC, Rotterdam, The Netherlands); Walter, T. (Department of Medical Oncology, H{\^o}pital Edouard Herriot, Lyon, France); Welin S. (Endocrine Oncology, University Hospital, Uppsala, Sweden). Open Access funding enabled and organized by Projekt DEAL. Publisher Copyright: {\textcopyright} 2023 The Authors. Journal of Neuroendocrinology published by John Wiley & Sons Ltd on behalf of British Society for Neuroendocrinology.",

year = "2023",

month = jun,

doi = "https://doi.org/10.1111/jne.13309",

language = "English",

volume = "35",

journal = "Journal of neuroendocrinology",

issn = "0953-8194",

publisher = "Wiley-Blackwell",

number = "6",

}

TY - JOUR

T1 - European Neuroendocrine Tumor Society (ENETS) 2023 guidance paper for colorectal neuroendocrine tumours

AU - Rinke, Anja

AU - Ambrosini, Valentina

AU - Dromain, Clarisse

AU - Garcia-Carbonero, Rocio

AU - Haji, Amyn

AU - Koumarianou, Anna

AU - van Dijkum, Els Nieveen

AU - O'Toole, Dermot

AU - Rindi, Guido

AU - Scoazec, Jean-Yves

AU - Ramage, John

N1 - Funding Information: We thank the members of the ENETS office for their support. The authors of this ENETS guidance paper are grateful to the ENETS Advisory Board members for their useful suggestions and comments in a common effort to improve the quality of the present manuscript. Following colleagues were participants of the ENETS guidance paper consensus meeting 13 October 2022: Bartsch, D. K. (Department of Visceral-, Thoracic- and Vascular Surgery Philipps-University Marburg, Marburg, Germany); Begum N. (Department for General-, Visceral-, Thoracic- and Endocrine Surgery, Johannes-Wesling-Klinikum Minden, University Hospital of the Ruhr-University Bochum, Germany); Capdevila, J. (Medical Oncology Department, Gastrointestinal and Endocrine Unit, Vall d'Hebron University Hospital, Barcelona, Spain); Caplin, M. (Neuroendocrine Tumour Unit, ENETS Center of Excellence, Royal Free Hospital and University College London, London, United Kingdom); Castaño, J. P. (Maimonides Biomedical Research Institute of Córdoba (IMIBIC), Reina Sofia University Hospital, University of Córdoba, Córdoba, Spain); Couvelard, A. (Pathology Department, Bichat Hospital, AP-HP and Université Paris Cité, Paris, France); Denecke T. (Universitätsklinikum Leipzig, Klinik für Diagnostische und Interventionelle Radiologie, Leipzig, Germany); Deroose, C. M. (University Hospitals Leuven, Nuclear Medicine and KU Leuven, Department of Imaging and Pathology, Nuclear Medicine & Molecular Imaging, Leuven, Belgium); Fazio, N. (Division of Gastrointestinal Medical Oncology and Neuroendocrine Tumours, European Institute of Oncology (IEO), IRCCS, Milan, Italy); Hofland, J. (Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands); Kaltsas, G. (1st Propaedeutic Department of Internal Medicine, National and Kapodistrian University of Athens, Athens, Greece); Kjaer, A. (Department of Clinical Physiology and Nuclear Medicine & Cluster for Molecular Imaging, Copenhagen University Hospital – Rigshospitalet & Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark); Knigge, U. (Departments of Surgery and Clinical Endocrinology, ENETS Center of Excellence, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark); Kos-Kudła, B. (Department of Endocrinology and Neuroendocrine Tumours, Medical University of Silesia, Katowice, Poland); Panzuto, F. (Department of Medical-Surgical Sciences and Translational Medicine, Sapienza University of Rome / Digestive Disease Unit, Sant'Andrea University Hospital, ENETS Center of Excellence, Rome, Italy); Pavel, M. (Department of Medicine 1, Universitätsklinikum Erlangen, Erlangen, Germany); Peeters M. (Antwerp University Hospital, Department of Oncology, Edegem, Belgium); Salazar R. (Institut Català d'Oncologia, Barcelona, Spain); Santos A. P. (Endocrinology Department, Endocrine Tumours Clinic, Precancerous Lesions and Early Cancer Management Group, RISE@CI-IPO (Health Research Network), Portuguese Oncology Institute of Porto (IPO Porto) / Porto Comprehensive Cancer Center (Porto.CCC), Porto, Portugal); Sorbye H. (Haukeland University Hospital, Dept. of Oncology, Bergen, Norway); Srirajaskanthan R. (Neuroendocrine Tumour Unit, Kings College Hospital / Department of Gastroenterology, Hambleden Wing, Kings College Hospital, London, United Kingdom); Sundin A. (Uppsala University, Surgical Sciences, Uppsala, Sweden); Tesselaar, M.E.T. (Department of Gastrointestinal Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands); Tiensuu Janson, E. (Department of Medical Sciences, Endocrine Oncology, Medical Faculty, Uppsala Universitet, Uppsala, Sweden); Toumpanakis, C. (Neuroendocrine Tumour Unit, ENETS Center of Excellence, Royal Free Hospital and University College London, London, United Kingdom); van Velthuysen, M. F. (Department of Pathology, Erasmus MC, Rotterdam, The Netherlands); Walter, T. (Department of Medical Oncology, Hôpital Edouard Herriot, Lyon, France); Welin S. (Endocrine Oncology, University Hospital, Uppsala, Sweden). Open Access funding enabled and organized by Projekt DEAL. Publisher Copyright: © 2023 The Authors. Journal of Neuroendocrinology published by John Wiley & Sons Ltd on behalf of British Society for Neuroendocrinology.

PY - 2023/6

Y1 - 2023/6

N2 - This ENETS guidance paper, developed by a multidisciplinary working group, provides an update on the previous colorectal guidance paper in a different format. Guided by key clinical questions practical advice on the diagnosis and management of neuroendocrine tumours (NET) of the caecum, colon, and rectum is provided. Although covered in one guidance paper colorectal NET comprises a heterogeneous group of neoplasms. The most common rectal NET are often small G1 tumours that can be treated by adequate endoscopic resection techniques. Evidence from prospective clinical trials on the treatment of metastatic colorectal NET is limited and discussion of patients in experienced multidisciplinary tumour boards strongly recommended. Neuroendocrine carcinomas (NEC) and mixed neuroendocrine non-neuroendocrine neoplasms (MiNEN) are discussed in a separate guidance paper.

AB - This ENETS guidance paper, developed by a multidisciplinary working group, provides an update on the previous colorectal guidance paper in a different format. Guided by key clinical questions practical advice on the diagnosis and management of neuroendocrine tumours (NET) of the caecum, colon, and rectum is provided. Although covered in one guidance paper colorectal NET comprises a heterogeneous group of neoplasms. The most common rectal NET are often small G1 tumours that can be treated by adequate endoscopic resection techniques. Evidence from prospective clinical trials on the treatment of metastatic colorectal NET is limited and discussion of patients in experienced multidisciplinary tumour boards strongly recommended. Neuroendocrine carcinomas (NEC) and mixed neuroendocrine non-neuroendocrine neoplasms (MiNEN) are discussed in a separate guidance paper.

KW - colorectal

KW - endoscopic treatment

KW - guideline

KW - neuroendocrine tumour

KW - rectal carcinoid

UR - http://www.scopus.com/inward/record.url?scp=85163223034&partnerID=8YFLogxK

U2 - https://doi.org/10.1111/jne.13309

DO - https://doi.org/10.1111/jne.13309

M3 - Article

C2 - 37345509

SN - 0953-8194

VL - 35

JO - Journal of neuroendocrinology

JF - Journal of neuroendocrinology

IS - 6

M1 - e13309

ER -

European Neuroendocrine Tumor Society (ENETS) 2023 guidance paper for colorectal neuroendocrine tumours

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