Challenges in the search for an HIV vaccine

Angelique A. C. Lemckert, Jaap Goudsmit, Dan H. Barouch

Research output: Contribution to JournalReview articleAcademicpeer-review

18 Citations (Scopus)

Abstract

Considerable progress has been made over the past several years in the development of an HIV vaccine. As a result, a growing number of vaccine modalities are being investigated in pre-clinical and phase I/II clinical trials. However, a number of major scientific challenges still remain. It is widely believed that the ideal vaccine should elicit both neutralizing antibodies and cytotoxic T lymphocytes (CTL) against diverse isolates of HIV, but the precise correlates of immunity have not been defined. Recombinant live vector-based vaccines and plasmid DNA vaccines have been shown to induce CTL, either alone or in combination, and these CTL-based vaccines have shown partial protective efficacy in nonhuman primates challenge studies. An immunogen that elicits broadly reactive neutralizing antibodies, however, has yet to be developed
Original languageEnglish
Pages (from-to)513-516
JournalEuropean journal of epidemiology
Volume19
Issue number6
Publication statusPublished - 2004

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