Changes over lactation in breast milk serum proteins involved in the maturation of immune and digestive system of the infant

Lina Zhang, Marita de Waard, Hester Verheijen, Sjef Boeren, Jos A. Hageman, Toon van Hooijdonk, Jacques Vervoort, Johannes B. van Goudoever, Kasper Hettinga

Research output: Contribution to journalArticleAcademicpeer-review

8 Citations (Scopus)


Here we provide data from shot-gun proteomics, using filtered-aided sample preparation (FASP), dimethyl labeling and LC-MS/MS, to quantify the changes in the repertoire of human milk proteins over lactation. Milk serum proteins were analyzed at week 1, 2, 3 4, 8, 16, and 24 in milk from four individual mothers. A total of 247 proteins were identified, of which 200 proteins were quantified. The data supplied in this article supports the accompanying publication (Zhang et al., 2006) [1]. The mass spectrometry proteomics data have been deposited to the ProteomeXchange Consortium (Vizcaíno et al., 2016) [2] via the PRIDE partner repository with the dataset identifier PXD003465.

Original languageEnglish
Pages (from-to)362-365
Number of pages4
JournalData in brief
Publication statusPublished - 1 Jun 2016


  • Gastrointestinal tract
  • Immune system
  • Milk serum proteome
  • Protease inhibitors

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