TY - JOUR
T1 - Chemokine Ligand 2 Genetic Variants, Serum Monocyte Chemoattractant Protein-1 Levels, and the Risk of Coronary Artery Disease
AU - van Wijk, Diederik F.
AU - van Leuven, Sander I.
AU - Sandhu, Manjinder S.
AU - Tanck, Michael W.
AU - Hutten, Barbara A.
AU - Wareham, Nicholas J.
AU - Kastelein, John J. P.
AU - Stroes, Erik S. G.
AU - Khaw, Kay-Tee
AU - Boekholdt, S. Matthijs
PY - 2010
Y1 - 2010
N2 - Objective-In humans, evidence about the association between levels of monocyte chemoattractant protein-1 (MCP-1), its coding gene chemokine (C-C motif) ligand 2 (CCL2), and risk of coronary artery disease (CAD) is contradictory. Methods and Results-We performed a nested case-control study in the prospective EPIC-Norfolk cohort investigating the relationship between CCL2 single-nucleotide polymorphisms (SNPs), MCP-1 concentrations, and the risk of future CAD. Cases (n = 1138) were apparently healthy men and women aged 45 to 79 years who developed fatal or nonfatal CAD during a mean follow-up of 6 years. Controls (n = 2237) were matched by age, sex, and enrollment time. Using linear regression analysis no association between CCL2 SNPs and MCP-1 serum concentrations became apparent, nor did we find a significant association between MCP-1 serum levels and risk of future CAD. Finally, Cox regression analysis showed no significant association between CCL2 SNPs and the future CAD risk. In addition, we did not find any robust associations between the CCL2 haplotypes and MCP-1 serum concentration or future CAD risk. Conclusion-Our data do not support previous publications indicating that MCP-1 is involved in the pathogenesis of CAD. (Arterioscler Thromb Vasc Biol. 2010; 30: 1460-1466.)
AB - Objective-In humans, evidence about the association between levels of monocyte chemoattractant protein-1 (MCP-1), its coding gene chemokine (C-C motif) ligand 2 (CCL2), and risk of coronary artery disease (CAD) is contradictory. Methods and Results-We performed a nested case-control study in the prospective EPIC-Norfolk cohort investigating the relationship between CCL2 single-nucleotide polymorphisms (SNPs), MCP-1 concentrations, and the risk of future CAD. Cases (n = 1138) were apparently healthy men and women aged 45 to 79 years who developed fatal or nonfatal CAD during a mean follow-up of 6 years. Controls (n = 2237) were matched by age, sex, and enrollment time. Using linear regression analysis no association between CCL2 SNPs and MCP-1 serum concentrations became apparent, nor did we find a significant association between MCP-1 serum levels and risk of future CAD. Finally, Cox regression analysis showed no significant association between CCL2 SNPs and the future CAD risk. In addition, we did not find any robust associations between the CCL2 haplotypes and MCP-1 serum concentration or future CAD risk. Conclusion-Our data do not support previous publications indicating that MCP-1 is involved in the pathogenesis of CAD. (Arterioscler Thromb Vasc Biol. 2010; 30: 1460-1466.)
U2 - https://doi.org/10.1161/ATVBAHA.110.205526
DO - https://doi.org/10.1161/ATVBAHA.110.205526
M3 - Article
C2 - 20431065
SN - 1079-5642
VL - 30
SP - 1460-U466
JO - Arteriosclerosis, Thrombosis, and Vascular Biology
JF - Arteriosclerosis, Thrombosis, and Vascular Biology
IS - 7
ER -