TY - JOUR
T1 - Cholestasis-Associated Pruritus and Its Pruritogens
AU - Langedijk, Jacqueline A. G. M.
AU - Beuers, Ulrich H.
AU - Oude Elferink, Ronald P. J.
N1 - Funding Information: Research on cholestasis-associated itch was funded by a TOP ZonMW grant (91210054) and by the Foundation Dioraphte (1115) to RO. Publisher Copyright: © Copyright © 2021 Langedijk, Beuers and Oude Elferink.
PY - 2021/3/9
Y1 - 2021/3/9
N2 - Pruritus is a debilitating symptom of various cholestatic disorders, including primary biliary cholangitis (PBC), primary sclerosing cholangitis (PSC) and inherited progressive familial intrahepatic cholestasis (PFIC). The molecular mechanisms leading to cholestasis-associated pruritus are still unresolved and the involved pruritogens are indecisive. As a consequence of pruritus, patients suffer from sleep deprivation, loss of daytime concentration, auto-mutilation and sometimes even suicidal ideations. Current guideline-approved therapy of cholestasis-associated pruritus includes stepwise administration of several medications, which may alleviate complaints in some, but not all affected patients. Therefore, also experimental therapeutic approaches are required to improve patients' quality of life. This article reviews the current state of research on pruritogens and their receptors, and shortly discusses the most recent experimental therapies.
AB - Pruritus is a debilitating symptom of various cholestatic disorders, including primary biliary cholangitis (PBC), primary sclerosing cholangitis (PSC) and inherited progressive familial intrahepatic cholestasis (PFIC). The molecular mechanisms leading to cholestasis-associated pruritus are still unresolved and the involved pruritogens are indecisive. As a consequence of pruritus, patients suffer from sleep deprivation, loss of daytime concentration, auto-mutilation and sometimes even suicidal ideations. Current guideline-approved therapy of cholestasis-associated pruritus includes stepwise administration of several medications, which may alleviate complaints in some, but not all affected patients. Therefore, also experimental therapeutic approaches are required to improve patients' quality of life. This article reviews the current state of research on pruritogens and their receptors, and shortly discusses the most recent experimental therapies.
KW - autotaxin
KW - bile formation
KW - cholestasis
KW - cholestasis-associated pruritus
KW - itch
KW - pruritogen
UR - http://www.scopus.com/inward/record.url?scp=85102952252&partnerID=8YFLogxK
U2 - https://doi.org/10.3389/fmed.2021.639674
DO - https://doi.org/10.3389/fmed.2021.639674
M3 - Review article
C2 - 33791327
SN - 2296-858X
VL - 8
JO - Frontiers in Medicine
JF - Frontiers in Medicine
M1 - 639674
ER -