Chronic microsensors for longitudinal, subsecond dopamine detection in behaving animals

Jeremy J. Clark; Stefan G. Sandberg; Matthew J. Wanat; Jerylin O. Gan; Eric A. Horne; Andrew S. Hart; Christina A. Akers; Jones G. Parker; Ingo Willuhn; Vicente Martinez; Scott B. Evans; Nephi Stella; Paul E. M. Phillips

doi:https://doi.org/10.1038/NMETH.1412

Chronic microsensors for longitudinal, subsecond dopamine detection in behaving animals

Jeremy J. Clark, Stefan G. Sandberg, Matthew J. Wanat, Jerylin O. Gan, Eric A. Horne, Andrew S. Hart, Christina A. Akers, Jones G. Parker, Ingo Willuhn, Vicente Martinez, Scott B. Evans, Nephi Stella, Paul E. M. Phillips

Research output: Contribution to journal › Article › Academic › peer-review

283 Citations (Scopus)

Abstract

Neurotransmission operates on a millisecond timescale but is changed by normal experience or neuropathology over days to months. Despite the importance of long-term neurotransmitter dynamics, no technique exists to track these changes in a subject from day to day over extended periods of time. Here we describe and characterize a microsensor that can detect the neurotransmitter dopamine with subsecond temporal resolution over months in vivo in rats and mice

Original language	English
Pages (from-to)	126-129
Journal	Nature methods
Volume	7
Issue number	2
DOIs	https://doi.org/10.1038/NMETH.1412
Publication status	Published - 2010
Externally published	Yes

Access to Document

https://doi.org/10.1038/NMETH.1412

Cite this

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title = "Chronic microsensors for longitudinal, subsecond dopamine detection in behaving animals",

abstract = "Neurotransmission operates on a millisecond timescale but is changed by normal experience or neuropathology over days to months. Despite the importance of long-term neurotransmitter dynamics, no technique exists to track these changes in a subject from day to day over extended periods of time. Here we describe and characterize a microsensor that can detect the neurotransmitter dopamine with subsecond temporal resolution over months in vivo in rats and mice",

author = "Clark, {Jeremy J.} and Sandberg, {Stefan G.} and Wanat, {Matthew J.} and Gan, {Jerylin O.} and Horne, {Eric A.} and Hart, {Andrew S.} and Akers, {Christina A.} and Parker, {Jones G.} and Ingo Willuhn and Vicente Martinez and Evans, {Scott B.} and Nephi Stella and Phillips, {Paul E. M.}",

year = "2010",

doi = "https://doi.org/10.1038/NMETH.1412",

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T1 - Chronic microsensors for longitudinal, subsecond dopamine detection in behaving animals

AU - Clark, Jeremy J.

AU - Sandberg, Stefan G.

AU - Wanat, Matthew J.

AU - Gan, Jerylin O.

AU - Horne, Eric A.

AU - Hart, Andrew S.

AU - Akers, Christina A.

AU - Parker, Jones G.

AU - Willuhn, Ingo

AU - Martinez, Vicente

AU - Evans, Scott B.

AU - Stella, Nephi

AU - Phillips, Paul E. M.

PY - 2010

Y1 - 2010

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AB - Neurotransmission operates on a millisecond timescale but is changed by normal experience or neuropathology over days to months. Despite the importance of long-term neurotransmitter dynamics, no technique exists to track these changes in a subject from day to day over extended periods of time. Here we describe and characterize a microsensor that can detect the neurotransmitter dopamine with subsecond temporal resolution over months in vivo in rats and mice

U2 - https://doi.org/10.1038/NMETH.1412

DO - https://doi.org/10.1038/NMETH.1412

M3 - Article

C2 - 20037591

SN - 1548-7091

VL - 7

SP - 126

EP - 129

JO - Nature methods

JF - Nature methods

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