Chronic microsensors for longitudinal, subsecond dopamine detection in behaving animals

Jeremy J. Clark, Stefan G. Sandberg, Matthew J. Wanat, Jerylin O. Gan, Eric A. Horne, Andrew S. Hart, Christina A. Akers, Jones G. Parker, Ingo Willuhn, Vicente Martinez, Scott B. Evans, Nephi Stella, Paul E. M. Phillips

Research output: Contribution to journalArticleAcademicpeer-review

267 Citations (Scopus)


Neurotransmission operates on a millisecond timescale but is changed by normal experience or neuropathology over days to months. Despite the importance of long-term neurotransmitter dynamics, no technique exists to track these changes in a subject from day to day over extended periods of time. Here we describe and characterize a microsensor that can detect the neurotransmitter dopamine with subsecond temporal resolution over months in vivo in rats and mice
Original languageEnglish
Pages (from-to)126-129
JournalNature methods
Issue number2
Publication statusPublished - 2010
Externally publishedYes

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