Classification of bipolar disorders-implications for clinical research

Ralph W. Kupka, Willem A. Nolen

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

1 Citation (Scopus)


The classification of mood disorders has been a subject of scientific debate for more than 2500 years (1,2), and a precise delineation of these illnesses and its various clinical manifestations has yet to emerge. Many aspects of this discussion have recently been reviewed by Akiskal (2) and supplemented by commentaries from authoritative researchers. In this chapter we will give an overview of the current classification, the boundaries of bipolar disorder with other major psychiatric illnesses, the validity and reliability of diagnosis, and the implications for neuropsychiatric research. As all classifications that are based on clinical description rather than on etiology and pathophysiology are deemed to be temporary, we will begin with a brief historical overview and end with some areas that need further clarification.

Original languageEnglish
Title of host publicationBipolar Disorders
Subtitle of host publicationBasic Mechanisms and Therapeutic Implications, Second Edition
PublisherCRC Press
Number of pages18
ISBN (Electronic)9781420021158
ISBN (Print)9780849398971
Publication statusPublished - 1 Jan 2007
Externally publishedYes

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