Clinical evaluation of vancomycin dosage in pediatric oncology patients

Stefan J. W. J. Sanders, Yuma A. Bijleveld, Fleur Sinkeler, Elles M. Kemper, Dasja Pajkrt, Marianne van de Wetering, Natasha K. A. van Eijkelenburg, Ron A. A. Mathôt

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Abstract

Vancomycin trough serum concentrations were below therapeutic range (8-15 mg/L) in 58% of 124 pediatric oncology patients receiving 60 mg/kg/d divided qid. Patients <6 and between 6 and 12 years had significantly lower trough concentrations than patients >12 years. A vancomycin dosage of 60 mg/kg/d is inadequate for pediatric oncology patients >12 years
Original languageEnglish
Pages (from-to)731-733
JournalPediatric Infectious Disease Journal
Volume33
Issue number7
DOIs
Publication statusPublished - 2014

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