Clinical evidence on haemodiafiltration

Peter J. Blankestijn, Muriel P. Grooteman, Menso J. Nube, Michiel L. Bots

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30 Citations (Scopus)


Haemodiafiltration (HDF) combines diffusive and convective solute removal in a single treatment session. HDF provides a greater removal of higher molecular weight uraemic retention solutes than conventional high-flux haemodialysis (HD). Recently completed randomized clinical trials suggest better patient survival with online HDF. The treatment is mainly used in Europe and Japan. This review gives a brief overview of the presently available evidence of the effects of HDF on clinical end points, it speculates on possible mechanisms of a beneficial effect of HDF as compared with standard HD and ends with some perspectives for the future.

Original languageEnglish
Pages (from-to)iii53-iii58
JournalNephrology dialysis transplantation
Publication statusPublished - 1 Oct 2018


  • chronic hemodialysis
  • clinical outcome
  • hemodiafiltration
  • online hemodiafiltration
  • review

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