TY - JOUR
T1 - Cognition in older adults with bipolar disorder
T2 - An ISBD task force systematic review and meta-analysis based on a comprehensive neuropsychological assessment
AU - Montejo, Laura
AU - Torrent, Carla
AU - Jiménez, Esther
AU - Martínez-Arán, Anabel
AU - Blumberg, Hilary P.
AU - Burdick, Katherine E.
AU - Chen, Peijun
AU - Dols, Annemieke
AU - Eyler, Lisa T.
AU - Forester, Brent P.
AU - Gatchel, Jennifer R.
AU - Gildengers, Ariel
AU - Kessing, Lars V.
AU - Miskowiak, Kamilla W.
AU - Olagunju, Andrew T.
AU - Patrick, Regan E.
AU - Schouws, Sigfried
AU - International Society for Bipolar Disorders (ISBD) Older Adults with Bipolar Disorder (OABD) Task Force
AU - Radua, Joaquim
AU - Bonnín, Caterina del M.
AU - Vieta, Eduard
N1 - Funding Information: AMA, CMB, CT, EJ, EV, and LM would like to thank the support of the Spanish Ministry of Science, the CIBER of Mental Health (CIBERSAM); the Comissionat per a Universitats I Recerca del DIUE de la Generalitat de Catalunya to the Bipolar Disorders Group (2017 1365), the CERCA Programme/Generalitat de Catalunya, and Instituto de Salud Carlos III for funding through the project PI20/00060. AG declared having received grant Support from the National Institute on Aging. BPF reports having received grant support from National Institute of Aging, Rogers Family Foundation, Spier Family Foundation, Biogen and, Eli Lilly. HPB also has received supported by National Institute of Mental Health of the National Institutes of Health under Award Number R01MH113230. JR was supported by the Spanish Ministry of Science, Innovation, and Universities / Economy and Competitiveness / Instituto de Salud Carlos III (CPII19/00009, PI19/00394), co-financed by ERDF Funds from the European Commission ("A Way of Making Europe"). KWM thanks the Lundbeck Foundation for her five-year Fellowship (grant no. R215-2015-4121). LTE is supported by the VA Desert-Pacific Mental Illness Research Education and Clinical Center. REP has received grant support from National Institute of Aging, Rogers Family Foundation, Biogen and Eli Lilly pharmaceuticals. Funding Information: AMA, CMB, CT, EJ, EV, and LM would like to thank the support of the Spanish Ministry of Science, the CIBER of Mental Health (CIBERSAM); the Comissionat per a Universitats I Recerca del DIUE de la Generalitat de Catalunya to the Bipolar Disorders Group (2017 1365), the CERCA Programme/Generalitat de Catalunya, and Instituto de Salud Carlos III for funding through the project PI20/00060. AG declared having received grant Support from the National Institute on Aging. BPF reports having received grant support from National Institute of Aging, Rogers Family Foundation, Spier Family Foundation, Biogen and, Eli Lilly. HPB also has received supported by National Institute of Mental Health of the National Institutes of Health under Award Number R01MH113230. JR was supported by the Spanish Ministry of Science, Innovation, and Universities / Economy and Competitiveness / Instituto de Salud Carlos III (CPII19/00009, PI19/00394), co‐financed by ERDF Funds from the European Commission ("A Way of Making Europe"). KWM thanks the Lundbeck Foundation for her five‐year Fellowship (grant no. R215‐2015‐4121). LTE is supported by the VA Desert‐Pacific Mental Illness Research Education and Clinical Center. REP has received grant support from National Institute of Aging, Rogers Family Foundation, Biogen and Eli Lilly pharmaceuticals. Publisher Copyright: © 2022 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
PY - 2022/3
Y1 - 2022/3
N2 - Objectives: We aim to characterize the cognitive performance in euthymic older adults with bipolar disorder (OABD) through a comprehensive neuropsychological assessment to obtain a detailed neuropsychological profile. Methods: We conducted a systematic search in MEDLINE/Pubmed, Cochrane, and PsycInfo databases. Original studies assessing cognitive function in OABD (age ≥50 years) containing, at a minimum, the domains of attention/processing speed, memory, and executive functions were included. A random-effects meta-analysis was conducted to summarize differences between patients and matched controls in each cognitive domain. We also conducted meta-regressions to estimate the impact of clinical and socio-demographic variables on these differences. Results: Eight articles, providing data for 328 euthymic OABD patients and 302 healthy controls, were included in the meta-analysis. OABD showed worse performance in comparison with healthy controls, with large significant effect sizes (Hedge's g from −0.77 to −0.89; p < 0.001) in verbal learning and verbal and visual delayed memory. They also displayed statistically significant deficits, with moderate effect size, in processing speed, working memory, immediate memory, cognitive flexibility, verbal fluency, psychomotor function, executive functions, attention, inhibition, and recognition (Hedge's g from −0.52 to −0.76; p < 0.001), but not in language and visuoconstruction domains. None of the examined variables were associated with these deficits. Conclusions: Cognitive dysfunction is present in OABD, with important deficits in almost all cognitive domains, especially in the memory domain. Our results highlight the importance of including a routine complete neuropsychological assessment in OABD and also considering therapeutic strategies in OABD.
AB - Objectives: We aim to characterize the cognitive performance in euthymic older adults with bipolar disorder (OABD) through a comprehensive neuropsychological assessment to obtain a detailed neuropsychological profile. Methods: We conducted a systematic search in MEDLINE/Pubmed, Cochrane, and PsycInfo databases. Original studies assessing cognitive function in OABD (age ≥50 years) containing, at a minimum, the domains of attention/processing speed, memory, and executive functions were included. A random-effects meta-analysis was conducted to summarize differences between patients and matched controls in each cognitive domain. We also conducted meta-regressions to estimate the impact of clinical and socio-demographic variables on these differences. Results: Eight articles, providing data for 328 euthymic OABD patients and 302 healthy controls, were included in the meta-analysis. OABD showed worse performance in comparison with healthy controls, with large significant effect sizes (Hedge's g from −0.77 to −0.89; p < 0.001) in verbal learning and verbal and visual delayed memory. They also displayed statistically significant deficits, with moderate effect size, in processing speed, working memory, immediate memory, cognitive flexibility, verbal fluency, psychomotor function, executive functions, attention, inhibition, and recognition (Hedge's g from −0.52 to −0.76; p < 0.001), but not in language and visuoconstruction domains. None of the examined variables were associated with these deficits. Conclusions: Cognitive dysfunction is present in OABD, with important deficits in almost all cognitive domains, especially in the memory domain. Our results highlight the importance of including a routine complete neuropsychological assessment in OABD and also considering therapeutic strategies in OABD.
KW - bipolar disorder
KW - cognition
KW - elderly
KW - meta-analysis
KW - neuropsychology
KW - older adults
KW - systematic review
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85122742053&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/34978124
UR - http://www.scopus.com/inward/record.url?scp=85122742053&partnerID=8YFLogxK
U2 - https://doi.org/10.1111/bdi.13175
DO - https://doi.org/10.1111/bdi.13175
M3 - Article
C2 - 34978124
SN - 1398-5647
VL - 24
SP - 115
EP - 136
JO - Bipolar disorders
JF - Bipolar disorders
IS - 2
ER -