TY - JOUR
T1 - Coma in adult cerebral venous thrombosis
T2 - The BEAST study
AU - Ranjan, Redoy
AU - Ken-Dror, Gie
AU - Martinelli, Ida
AU - Grandone, Elvira
AU - Hiltunen, Sini
AU - Lindgren, Erik
AU - Margaglione, Maurizio
AU - Duchez, Veronique Le Cam
AU - Triquenot Bagan, Aude
AU - Zedde, Marialuisa
AU - Giannini, Nicola
AU - Ruigrok, Ynte M.
AU - Worrall, Bradford B.
AU - Majersik, Jennifer J.
AU - Putaala, Jukka
AU - Haapaniemi, Elena
AU - Zuurbier, Susanna M.
AU - Brouwer, Matthijs C.
AU - Passamonti, Serena M.
AU - Abbattista, Maria
AU - Bucciarelli, Paolo
AU - Lemmens, Robin
AU - Pappalardo, Emanuela
AU - Costa, Paolo
AU - Colombi, Marina
AU - Aguiar de Sousa, Diana
AU - Rodrigues, Sofia
AU - Canhão, Patrícia
AU - Tkach, Aleksander
AU - Santacroce, Rosa
AU - Favuzzi, Giovanni
AU - Arauz, Antonio
AU - Colaizzo, Donatella
AU - Spengos, Kostas
AU - Hodge, Amanda
AU - Ditta, Reina
AU - Pezzini, Alessandro
AU - Coutinho, Jonathan M.
AU - Thijs, Vincent
AU - Jood, Katarina
AU - Tatlisumak, Turgut
AU - Ferro, José M.
AU - Sharma, Pankaj
N1 - Publisher Copyright: © 2024 The Authors. European Journal of Neurology published by John Wiley & Sons Ltd on behalf of European Academy of Neurology.
PY - 2024
Y1 - 2024
N2 - Background and purpose: Coma is an independent predictor of poor clinical outcomes in cerebral venous thrombosis (CVT). We aimed to describe the association of age, sex, and radiological characteristics of adult coma patients with CVT. Methods: We used data from the international, multicentre prospective observational BEAST (Biorepository to Establish the Aetiology of Sinovenous Thrombosis) study. Only positively associated variables with coma with <10% missing data in univariate analysis were considered for the multivariate logistic regression model. Results: Of the 596 adult patients with CVT (75.7% women), 53 (8.9%) patients suffered coma. Despite being a female-predominant disease, the prevalence of coma was higher among men than women (13.1% vs. 7.5%, p = 0.04). Transverse sinus thrombosis was least likely to be associated with coma (23.9% vs. 73.3%, p < 0.001). The prevalence of superior sagittal sinus thrombosis was higher among men than women in the coma sample (73.6% vs. 37.5%, p = 0.01). Men were significantly older than women, with a median (interquartile range) age of 51 (38.5–60) versus 40 (33–47) years in the coma (p = 0.04) and 44.5 (34–58) versus 37 (29–48) years in the non-coma sample (p < 0.001), respectively. Furthermore, an age- and superior sagittal sinus-adjusted multivariate logistic regression model found male sex (odds ratio = 1.8, 95% confidence interval [CI] = 1.0–3.4, p = 0.04) to be an independent predictor of coma in CVT, with an area under the receiver operating characteristic curve of 0.61 (95% CI = 0.52–0.68, p = 0.01). Conclusions: Although CVT is a female-predominant disease, men were older and nearly twice as likely to suffer from coma than women.
AB - Background and purpose: Coma is an independent predictor of poor clinical outcomes in cerebral venous thrombosis (CVT). We aimed to describe the association of age, sex, and radiological characteristics of adult coma patients with CVT. Methods: We used data from the international, multicentre prospective observational BEAST (Biorepository to Establish the Aetiology of Sinovenous Thrombosis) study. Only positively associated variables with coma with <10% missing data in univariate analysis were considered for the multivariate logistic regression model. Results: Of the 596 adult patients with CVT (75.7% women), 53 (8.9%) patients suffered coma. Despite being a female-predominant disease, the prevalence of coma was higher among men than women (13.1% vs. 7.5%, p = 0.04). Transverse sinus thrombosis was least likely to be associated with coma (23.9% vs. 73.3%, p < 0.001). The prevalence of superior sagittal sinus thrombosis was higher among men than women in the coma sample (73.6% vs. 37.5%, p = 0.01). Men were significantly older than women, with a median (interquartile range) age of 51 (38.5–60) versus 40 (33–47) years in the coma (p = 0.04) and 44.5 (34–58) versus 37 (29–48) years in the non-coma sample (p < 0.001), respectively. Furthermore, an age- and superior sagittal sinus-adjusted multivariate logistic regression model found male sex (odds ratio = 1.8, 95% confidence interval [CI] = 1.0–3.4, p = 0.04) to be an independent predictor of coma in CVT, with an area under the receiver operating characteristic curve of 0.61 (95% CI = 0.52–0.68, p = 0.01). Conclusions: Although CVT is a female-predominant disease, men were older and nearly twice as likely to suffer from coma than women.
KW - CVT
KW - cerebral venous thrombosis
KW - characteristics
KW - coma
KW - predictors
KW - women
UR - http://www.scopus.com/inward/record.url?scp=85191200076&partnerID=8YFLogxK
U2 - 10.1111/ene.16311
DO - 10.1111/ene.16311
M3 - Article
C2 - 38646961
SN - 1351-5101
JO - European journal of neurology
JF - European journal of neurology
ER -