Combination of serum markers related to several mechanisms in Alzheimer's disease

C. E. Teunissen; D. Lütjohann; K. Von Bergmann; F. Verhey; F. Vreeling; A. Wauters; E. Bosmans; H. Bosma; M. P.J. Van Boxtel; M. Maes; J. Delanghe; H. J. Blom; M. M. Verbeek; P. Rieckmann; C. De Bruijn; H. W.M. Steinbusch; J. De Vente

doi:https://doi.org/10.1016/S0197-4580(03)00005-8

Combination of serum markers related to several mechanisms in Alzheimer's disease

C. E. Teunissen, D. Lütjohann, K. Von Bergmann, F. Verhey, F. Vreeling, A. Wauters, E. Bosmans, H. Bosma, M. P.J. Van Boxtel, M. Maes, J. Delanghe, H. J. Blom, M. M. Verbeek, P. Rieckmann, C. De Bruijn, H. W.M. Steinbusch, J. De Vente

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Abstract

Alzheimer's disease (AD) probably involves several pathobiochemical mechanisms and this may be reflected by changes in different serum components. The present study investigated whether the combined analysis of serum molecules related to different mechanisms improves the discrimination of AD patients from healthy controls. Serum of patients with AD was analyzed for a broad spectrum of marker molecules, including 11 inflammatory proteins, 12 sterol intermediates and phytosterols, 2 brain-specific proteins and 4 constituents involved in homocysteine homeostasis. The serum molecule concentrations were combined in a logistic regression model, using a forward stepwise inclusion mode. The results showed that the combination of interleukin-6 (IL-6) receptor, protein α1 fraction, cysteine and cholesterol concentrations improved the discrimination between AD patients and healthy controls compared to the single markers. In conclusion, the results of this study have shown that the complex pathology in AD is reflected in a pattern of altered serum concentrations of several marker molecules related to several pathobiochemical mechanisms.

Original language	English
Pages (from-to)	893-902
Number of pages	10
Journal	Neurobiology of aging
Volume	24
Issue number	7
DOIs	https://doi.org/10.1016/S0197-4580(03)00005-8
Publication status	Published - Nov 2003

Keywords

Alzheimer's disease
Cholesterol homeostasis
Combined marker analysis
Homocysteine
Inflammation
Serum

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https://doi.org/10.1016/S0197-4580(03)00005-8

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Teunissen, C. E., Lütjohann, D., Von Bergmann, K., Verhey, F., Vreeling, F., Wauters, A., Bosmans, E., Bosma, H., Van Boxtel, M. P. J., Maes, M., Delanghe, J., Blom, H. J., Verbeek, M. M., Rieckmann, P., De Bruijn, C., Steinbusch, H. W. M., & De Vente, J. (2003). Combination of serum markers related to several mechanisms in Alzheimer's disease. Neurobiology of aging, 24(7), 893-902. https://doi.org/10.1016/S0197-4580(03)00005-8

@article{f0324fbc16744e2b87f2d44b8181ea2a,

title = "Combination of serum markers related to several mechanisms in Alzheimer's disease",

abstract = "Alzheimer's disease (AD) probably involves several pathobiochemical mechanisms and this may be reflected by changes in different serum components. The present study investigated whether the combined analysis of serum molecules related to different mechanisms improves the discrimination of AD patients from healthy controls. Serum of patients with AD was analyzed for a broad spectrum of marker molecules, including 11 inflammatory proteins, 12 sterol intermediates and phytosterols, 2 brain-specific proteins and 4 constituents involved in homocysteine homeostasis. The serum molecule concentrations were combined in a logistic regression model, using a forward stepwise inclusion mode. The results showed that the combination of interleukin-6 (IL-6) receptor, protein α1 fraction, cysteine and cholesterol concentrations improved the discrimination between AD patients and healthy controls compared to the single markers. In conclusion, the results of this study have shown that the complex pathology in AD is reflected in a pattern of altered serum concentrations of several marker molecules related to several pathobiochemical mechanisms.",

keywords = "Alzheimer's disease, Cholesterol homeostasis, Combined marker analysis, Homocysteine, Inflammation, Serum",

author = "Teunissen, {C. E.} and D. L{\"u}tjohann and {Von Bergmann}, K. and F. Verhey and F. Vreeling and A. Wauters and E. Bosmans and H. Bosma and {Van Boxtel}, {M. P.J.} and M. Maes and J. Delanghe and Blom, {H. J.} and Verbeek, {M. M.} and P. Rieckmann and {De Bruijn}, C. and Steinbusch, {H. W.M.} and {De Vente}, J.",

note = "Funding Information: This study was supported by the “Van Leersum fonds” of the Royal academy of Sciences, The Netherlands.",

year = "2003",

month = nov,

doi = "https://doi.org/10.1016/S0197-4580(03)00005-8",

language = "English",

volume = "24",

pages = "893--902",

journal = "Neurobiology of aging",

issn = "0197-4580",

publisher = "Elsevier Inc.",

number = "7",

}

Teunissen, CE, Lütjohann, D, Von Bergmann, K, Verhey, F, Vreeling, F, Wauters, A, Bosmans, E, Bosma, H, Van Boxtel, MPJ, Maes, M, Delanghe, J, Blom, HJ, Verbeek, MM, Rieckmann, P, De Bruijn, C, Steinbusch, HWM & De Vente, J 2003, 'Combination of serum markers related to several mechanisms in Alzheimer's disease', Neurobiology of aging, vol. 24, no. 7, pp. 893-902. https://doi.org/10.1016/S0197-4580(03)00005-8

TY - JOUR

T1 - Combination of serum markers related to several mechanisms in Alzheimer's disease

AU - Teunissen, C. E.

AU - Lütjohann, D.

AU - Von Bergmann, K.

AU - Verhey, F.

AU - Vreeling, F.

AU - Wauters, A.

AU - Bosmans, E.

AU - Bosma, H.

AU - Van Boxtel, M. P.J.

AU - Maes, M.

AU - Delanghe, J.

AU - Blom, H. J.

AU - Verbeek, M. M.

AU - Rieckmann, P.

AU - De Bruijn, C.

AU - Steinbusch, H. W.M.

AU - De Vente, J.

N1 - Funding Information: This study was supported by the “Van Leersum fonds” of the Royal academy of Sciences, The Netherlands.

PY - 2003/11

Y1 - 2003/11

N2 - Alzheimer's disease (AD) probably involves several pathobiochemical mechanisms and this may be reflected by changes in different serum components. The present study investigated whether the combined analysis of serum molecules related to different mechanisms improves the discrimination of AD patients from healthy controls. Serum of patients with AD was analyzed for a broad spectrum of marker molecules, including 11 inflammatory proteins, 12 sterol intermediates and phytosterols, 2 brain-specific proteins and 4 constituents involved in homocysteine homeostasis. The serum molecule concentrations were combined in a logistic regression model, using a forward stepwise inclusion mode. The results showed that the combination of interleukin-6 (IL-6) receptor, protein α1 fraction, cysteine and cholesterol concentrations improved the discrimination between AD patients and healthy controls compared to the single markers. In conclusion, the results of this study have shown that the complex pathology in AD is reflected in a pattern of altered serum concentrations of several marker molecules related to several pathobiochemical mechanisms.

AB - Alzheimer's disease (AD) probably involves several pathobiochemical mechanisms and this may be reflected by changes in different serum components. The present study investigated whether the combined analysis of serum molecules related to different mechanisms improves the discrimination of AD patients from healthy controls. Serum of patients with AD was analyzed for a broad spectrum of marker molecules, including 11 inflammatory proteins, 12 sterol intermediates and phytosterols, 2 brain-specific proteins and 4 constituents involved in homocysteine homeostasis. The serum molecule concentrations were combined in a logistic regression model, using a forward stepwise inclusion mode. The results showed that the combination of interleukin-6 (IL-6) receptor, protein α1 fraction, cysteine and cholesterol concentrations improved the discrimination between AD patients and healthy controls compared to the single markers. In conclusion, the results of this study have shown that the complex pathology in AD is reflected in a pattern of altered serum concentrations of several marker molecules related to several pathobiochemical mechanisms.

KW - Alzheimer's disease

KW - Cholesterol homeostasis

KW - Combined marker analysis

KW - Homocysteine

KW - Inflammation

KW - Serum

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U2 - https://doi.org/10.1016/S0197-4580(03)00005-8

DO - https://doi.org/10.1016/S0197-4580(03)00005-8

M3 - Article

C2 - 12928047

SN - 0197-4580

VL - 24

SP - 893

EP - 902

JO - Neurobiology of aging

JF - Neurobiology of aging

IS - 7

ER -

Combination of serum markers related to several mechanisms in Alzheimer's disease

Abstract

Keywords

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