Combinatorial Antigen Targeting: Ideal T-Cell Sensing and Anti-Tumor Response

Maria Themeli; Michel Sadelain

doi:https://doi.org/10.1016/j.molmed.2016.02.009

Combinatorial Antigen Targeting: Ideal T-Cell Sensing and Anti-Tumor Response

Maria Themeli, Michel Sadelain

Research output: Contribution to journal › Article › Academic

11 Citations (Scopus)

Abstract

T cells expressing chimeric antigen receptors (CARs) are a formidable platform for the study and application of synthetic biology approaches to study customized and flexible control of cellular functions. Recent reports in the journal Cell provide a new twist on combinatorial antigen targeting, profiting from the singular cleavage and signaling of the Notch receptor to conditionally express CARs.

Original language	English
Pages (from-to)	271-273
Number of pages	3
Journal	Trends in molecular medicine
Volume	22
Issue number	4
DOIs	https://doi.org/10.1016/j.molmed.2016.02.009
Publication status	Published - Apr 2016

Keywords

Animals
Cell Engineering
Humans
Immunotherapy/methods
Neoplasms/immunology
Receptors, Notch/chemistry
Signal Transduction
Synthetic Biology/methods
T-Lymphocytes/metabolism

Access to Document

https://doi.org/10.1016/j.molmed.2016.02.009

Cite this

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title = "Combinatorial Antigen Targeting: Ideal T-Cell Sensing and Anti-Tumor Response",

abstract = "T cells expressing chimeric antigen receptors (CARs) are a formidable platform for the study and application of synthetic biology approaches to study customized and flexible control of cellular functions. Recent reports in the journal Cell provide a new twist on combinatorial antigen targeting, profiting from the singular cleavage and signaling of the Notch receptor to conditionally express CARs. ",

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KW - Immunotherapy/methods

KW - Neoplasms/immunology

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KW - T-Lymphocytes/metabolism

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