Combinatorial Antigen Targeting: Ideal T-Cell Sensing and Anti-Tumor Response

Maria Themeli, Michel Sadelain

Research output: Contribution to journalArticleAcademic

11 Citations (Scopus)


T cells expressing chimeric antigen receptors (CARs) are a formidable platform for the study and application of synthetic biology approaches to study customized and flexible control of cellular functions. Recent reports in the journal Cell provide a new twist on combinatorial antigen targeting, profiting from the singular cleavage and signaling of the Notch receptor to conditionally express CARs.

Original languageEnglish
Pages (from-to)271-273
Number of pages3
JournalTrends in molecular medicine
Issue number4
Publication statusPublished - Apr 2016


  • Animals
  • Cell Engineering
  • Humans
  • Immunotherapy/methods
  • Neoplasms/immunology
  • Receptors, Notch/chemistry
  • Signal Transduction
  • Synthetic Biology/methods
  • T-Lymphocytes/metabolism

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