Combining a CAR and a chimeric costimulatory receptor enhances T cell sensitivity to low antigen density and promotes persistence

Afroditi Katsarou; Maria Sjöstrand; Jyoti Naik; Jorge Mansilla-Soto; Dionysia Kefala; Georgios Kladis; Alexandros Nianias; Ruud Ruiter; Renée Poels; Irene Sarkar; Yash R. Patankar; Elena Merino; Rogier M. Reijmers; Kristine A. Frerichs; Huipin Yuan; Joost de Bruijn; Dina Stroopinsky; David Avigan; Niels W. C. J. van de Donk; Sonja Zweegman; Tuna Mutis; Michel Sadelain; Richard W. J. Groen; Maria Themeli

doi:https://doi.org/10.1126/scitranslmed.abh1962

Combining a CAR and a chimeric costimulatory receptor enhances T cell sensitivity to low antigen density and promotes persistence

Afroditi Katsarou, Maria Sjöstrand, Jyoti Naik, Jorge Mansilla-Soto, Dionysia Kefala, Georgios Kladis, Alexandros Nianias, Ruud Ruiter, Renée Poels, Irene Sarkar, Yash R. Patankar, Elena Merino, Rogier M. Reijmers, Kristine A. Frerichs, Huipin Yuan, Joost de Bruijn, Dina Stroopinsky, David Avigan, Niels W. C. J. van de Donk, Sonja ZweegmanTuna Mutis, Michel Sadelain, Richard W. J. Groen, Maria Themeli

Research output: Contribution to journal › Article › Academic › peer-review

45 Citations (Scopus)

Abstract

[Figure: see text].

Original language	English
Pages (from-to)	eabh1962
Journal	Science Translational Medicine
Volume	13
Issue number	623
DOIs	https://doi.org/10.1126/scitranslmed.abh1962
Publication status	Published - 8 Dec 2021

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Katsarou, A., Sjöstrand, M., Naik, J., Mansilla-Soto, J., Kefala, D., Kladis, G., Nianias, A., Ruiter, R., Poels, R., Sarkar, I., Patankar, Y. R., Merino, E., Reijmers, R. M., Frerichs, K. A., Yuan, H., de Bruijn, J., Stroopinsky, D., Avigan, D., van de Donk, N. W. C. J., ... Themeli, M. (2021). Combining a CAR and a chimeric costimulatory receptor enhances T cell sensitivity to low antigen density and promotes persistence. Science Translational Medicine, 13(623), eabh1962. https://doi.org/10.1126/scitranslmed.abh1962

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Katsarou, A, Sjöstrand, M, Naik, J, Mansilla-Soto, J, Kefala, D, Kladis, G , Nianias, A, Ruiter, R, Poels, R, Sarkar, I, Patankar, YR, Merino, E, Reijmers, RM, Frerichs, KA, Yuan, H, de Bruijn, J, Stroopinsky, D, Avigan, D, van de Donk, NWCJ , Zweegman, S , Mutis, T, Sadelain, M, Groen, RWJ & Themeli, M 2021, 'Combining a CAR and a chimeric costimulatory receptor enhances T cell sensitivity to low antigen density and promotes persistence', Science Translational Medicine, vol. 13, no. 623, pp. eabh1962. https://doi.org/10.1126/scitranslmed.abh1962

TY - JOUR

T1 - Combining a CAR and a chimeric costimulatory receptor enhances T cell sensitivity to low antigen density and promotes persistence

AU - Katsarou, Afroditi

AU - Sjöstrand, Maria

AU - Naik, Jyoti

AU - Mansilla-Soto, Jorge

AU - Kefala, Dionysia

AU - Kladis, Georgios

AU - Nianias, Alexandros

AU - Ruiter, Ruud

AU - Poels, Renée

AU - Sarkar, Irene

AU - Patankar, Yash R.

AU - Merino, Elena

AU - Reijmers, Rogier M.

AU - Frerichs, Kristine A.

AU - Yuan, Huipin

AU - de Bruijn, Joost

AU - Stroopinsky, Dina

AU - Avigan, David

AU - van de Donk, Niels W. C. J.

AU - Zweegman, Sonja

AU - Mutis, Tuna

AU - Sadelain, Michel

AU - Groen, Richard W. J.

AU - Themeli, Maria

PY - 2021/12/8

Y1 - 2021/12/8

N2 - [Figure: see text].

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U2 - https://doi.org/10.1126/scitranslmed.abh1962

DO - https://doi.org/10.1126/scitranslmed.abh1962

M3 - Article

C2 - 34878825

SN - 1946-6234

VL - 13

SP - eabh1962

JO - Science Translational Medicine

JF - Science Translational Medicine

IS - 623

ER -

Combining a CAR and a chimeric costimulatory receptor enhances T cell sensitivity to low antigen density and promotes persistence

Abstract

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