Common variants at 11p13 are associated with susceptibility to tuberculosis

Thorsten Thye, Ellis Owusu-Dabo, Fredrik O Vannberg, Reinout van Crevel, James Curtis, Edhyana Sahiratmadja, Yanina Balabanova, Christa Ehmen, Birgit Muntau, Gerd Ruge, Jürgen Sievertsen, John Gyapong, Vladyslav Nikolayevskyy, Philip C Hill, Giorgio Sirugo, Francis Drobniewski, Esther van de Vosse, Melanie Newport, Bachti Alisjahbana, Sergey NejentsevTom H M Ottenhoff, Adrian V S Hill, Rolf D Horstmann, Christian G Meyer

Research output: Contribution to journalArticleAcademicpeer-review

166 Citations (Scopus)


After imputation of data from the 1000 Genomes Project into a genome-wide dataset of Ghanaian individuals with tuberculosis and controls, we identified a resistance locus on chromosome 11p13 downstream of the WT1 gene (encoding Wilms tumor 1). The strongest signal was obtained at the rs2057178 SNP (P = 2.63 × 10(-9)). Replication in Gambian, Indonesian and Russian tuberculosis case-control study cohorts increased the significance level for the association with this SNP to P = 2.57 × 10(-11).

Original languageEnglish
Pages (from-to)257-9
Number of pages3
JournalNature Genetics
Issue number3
Publication statusPublished - 5 Feb 2012
Externally publishedYes


  • Case-Control Studies
  • Chromosomes, Human, Pair 11/genetics
  • Cohort Studies
  • Genetic Predisposition to Disease/genetics
  • Genetic Variation/genetics
  • Genotype
  • Ghana
  • Humans
  • Models, Genetic
  • Nuclear Proteins/genetics
  • Polymorphism, Single Nucleotide/genetics
  • Tuberculosis/genetics

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