@article{e34a06a06b19441daa3b3769ecc12807,
title = "Comparable endemic coronavirus nucleoprotein-specific antibodies in mild and severe Covid-19 patients",
abstract = "The severity of disease of Covid-19 is highly variable, ranging from asymptomatic to critical respiratory disease and death. Potential cross-reactive immune responses between SARS-CoV-2 and endemic coronavirus (eCoV) may hypothetically contribute to this variability. We herein studied if eCoV nucleoprotein (N)-specific antibodies in the sera of patients with mild or severe Covid-19 are associated with Covid-19 severity. There were comparable levels of eCoV N-specific antibodies early and during the first month of infection in Covid-19 patients with mild and severe symptoms, and healthy SARS-CoV-2-negative subjects. These results warrant further studies to investigate the potential role of eCoV-specific antibodies in immunity to SARS-CoV-2 infection.",
keywords = "COVID-19, disease severity, endemic coronaviruses, nucleoprotein-specific antibodies",
author = "Susannah Leach and Harandi, {Ali M.} and Tomas Bergstr{\"o}m and Lars-Magnus Andersson and Staffan Nilsson and {van der Hoek}, Lia and Magnus Gissl{\'e}n",
note = "Funding Information: This study was supported by the Swedish State Support for Clinical Research ( https://www.alfvastragotaland.se , ALFGBG‐717531 [Magnus Gissl{\'e}n] and 679621 [Susannah Leach]), SciLifeLab/KAW national COVID‐19 research program ( https://www.scilifelab.se/covid-19#nationalprogram , V‐2020‐ 0250 [Magnus Gissl{\'e}n]) and Sweden's Innovation Agency (Vinnova) project ID 2020‐02205 (Ali M. Harandi). The funders had no role in study design, data collection, and analysis, decision to publish, or preparation of the manuscript. Publisher Copyright: {\textcopyright} 2021 The Authors. Journal of Medical Virology published by Wiley Periodicals LLC Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",
year = "2021",
month = sep,
doi = "https://doi.org/10.1002/jmv.27038",
language = "English",
volume = "93",
pages = "5614--5617",
journal = "Journal of Medical Virology",
issn = "0146-6615",
publisher = "Wiley-Liss Inc.",
number = "9",
}