TY - JOUR
T1 - Comparing cardiovascular disease incidence and prevalence between depressed and non-depressed older persons over time
T2 - Cohort differences in the Longitudinal Aging Study Amsterdam
AU - van Zutphen, E.M.
AU - Kok, A.A.L.
AU - Rhebergen, D.
AU - van Schoor, N.M.
AU - Huisman, M.
AU - Beekman, A.T.F.
N1 - Funding Information: The Longitudinal Aging Study Amsterdam is supported by a grant from the Netherlands Ministry of Health, Welfare and Sport, Directorate of Long-Term Care. The data collection in 2012–2013 was financially supported by the Netherlands Organization for Scientific Research (NWO) in the framework of the project “New Cohorts of young old in the 21st century” (file number 480-10-014). The funders had no role in study design, data collection, analysis and interpretation, decision to publish, or preparation of the manuscript. The authors of this paper did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors and have no competing interests to report. Funding Information: The Longitudinal Aging Study Amsterdam is supported by a grant from the Netherlands Ministry of Health, Welfare and Sport , Directorate of Long-Term Care. The data collection in 2012–2013 was financially supported by the Netherlands Organization for Scientific Research (NWO) in the framework of the project “New Cohorts of young old in the 21st century” (file number 480-10-014 ). The funders had no role in study design, data collection, analysis and interpretation, decision to publish, or preparation of the manuscript. The authors of this paper did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors and have no competing interests to report. Publisher Copyright: © 2022 The Authors
PY - 2022/11/1
Y1 - 2022/11/1
N2 - © 2022 The AuthorsObjective: Previous studies suggest that prevention of cardiovascular disease (CVD) is more difficult in depressed persons. Although the prevalence and incidence of CVD decreased over the past decades, it is uncertain whether this is also true for depressed persons. This study examined whether changes in the prevalence and incidence of CVD differ between depressed and non-depressed older persons. Methods: Longitudinal data from three community-based representative birth cohorts aged 55–65 years of the Longitudinal Aging Study Amsterdam were used; N = 1070 born in 1926–1937, N = 995 born in 1938–1947, N = 1019 born in 1948–1957. The outcome included fatal and non-fatal CVD. Depression was defined as ≥16 points on the Center for Epidemiological Studies Depression Scale or a general practitioner's diagnosis of depression. Data were analysed with for age and sex adjusted logistic regression and cox regression models. Results: Comparing cohort 2 and 3 with cohort 1 in the complete sample, the prevalence of CVD decreased by 2% (OR = 0.98, 95%CI = 0.76–1.26) and 32% (OR = 0.68, 95%CI = 0.52–0.89), respectively, and the three-year incidence of CVD decreased by 6% (OR = 0.94, 95%CI = 0.63–1.41) and 26% (OR = 0.74, 95%CI = 0.48–1.15), respectively. The 13-year incidence of CVD decreased by 19% (HR = 0.81, 95%CI = 0.67–0.99) in cohort 2 compared to cohort 1. These decreases did not differ statistically significantly between depressed and non-depressed respondents (p-values of interaction terms: 0.35–0.98). Conclusion: Substantial decreases in the prevalence and incidence of CVD were observed in depressed and non-depressed older persons. Although this is encouraging, cardiovascular risk remained higher in depressed persons over time, warranting tailored prevention programs for depressed older persons.
AB - © 2022 The AuthorsObjective: Previous studies suggest that prevention of cardiovascular disease (CVD) is more difficult in depressed persons. Although the prevalence and incidence of CVD decreased over the past decades, it is uncertain whether this is also true for depressed persons. This study examined whether changes in the prevalence and incidence of CVD differ between depressed and non-depressed older persons. Methods: Longitudinal data from three community-based representative birth cohorts aged 55–65 years of the Longitudinal Aging Study Amsterdam were used; N = 1070 born in 1926–1937, N = 995 born in 1938–1947, N = 1019 born in 1948–1957. The outcome included fatal and non-fatal CVD. Depression was defined as ≥16 points on the Center for Epidemiological Studies Depression Scale or a general practitioner's diagnosis of depression. Data were analysed with for age and sex adjusted logistic regression and cox regression models. Results: Comparing cohort 2 and 3 with cohort 1 in the complete sample, the prevalence of CVD decreased by 2% (OR = 0.98, 95%CI = 0.76–1.26) and 32% (OR = 0.68, 95%CI = 0.52–0.89), respectively, and the three-year incidence of CVD decreased by 6% (OR = 0.94, 95%CI = 0.63–1.41) and 26% (OR = 0.74, 95%CI = 0.48–1.15), respectively. The 13-year incidence of CVD decreased by 19% (HR = 0.81, 95%CI = 0.67–0.99) in cohort 2 compared to cohort 1. These decreases did not differ statistically significantly between depressed and non-depressed respondents (p-values of interaction terms: 0.35–0.98). Conclusion: Substantial decreases in the prevalence and incidence of CVD were observed in depressed and non-depressed older persons. Although this is encouraging, cardiovascular risk remained higher in depressed persons over time, warranting tailored prevention programs for depressed older persons.
KW - Cardiovascular disease
KW - Depression
KW - Incidence
KW - Prevalence
KW - Time trends
UR - http://www.scopus.com/inward/record.url?scp=85138375837&partnerID=8YFLogxK
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85138375837&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/36162162
U2 - https://doi.org/10.1016/j.jpsychores.2022.111015
DO - https://doi.org/10.1016/j.jpsychores.2022.111015
M3 - Article
C2 - 36162162
SN - 0022-3999
VL - 162
SP - 1
EP - 8
JO - Journal of psychosomatic research
JF - Journal of psychosomatic research
M1 - 111015
ER -
