Comparison of commercial diagnostic tests for identification of serogroup antigens of Neisseria meningitidis

A. van der Ende, I. G. Schuurman, C. T. Hopman, C. A. Fijen, J. Dankert

Research output: Contribution to journalComment/Letter to the editorAcademic

17 Citations (Scopus)

Abstract

In the study that is described the sensitivities and specificities of three commercial tests and the standard Reference Laboratory test, used since 1961, to identify Neisseria meningitidis serogroups were compared. The tests marketed by Difco, Murex/Wellcome, and Sanofi/Pasteur showed overall sensitivities of 92, 95, and 100%, respectively, and specificities of 67, 88, and 82%, respectively. When limited to the common serogroups A, B, and C, the three tests yielded sensitivities of 93, 97, and 100%, respectively, and specificities of 98, 100, and 98%, respectively. However, determination of the uncommon serogroups X, W-135, Y, Z, and 29E with these tests is either unreliable or not possible
Original languageEnglish
Pages (from-to)3326-3327
JournalJournal of clinical microbiology
Volume33
Issue number12
Publication statusPublished - 1995

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