Comparison of conformal radiation therapy techniques within the dynamic radiotherapy project 'Dynarad'

P. Mavroidis, B. K. Lind, J. van Dijk, K. Koedooder, W. de Neve, C. de Wagter, B. Planskoy, J. C. Rosenwald, B. Proimos, C. Kappas, D. Claudia, M. Benassi, G. Chierego, A. Brahme

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

The objective of the dynamic radiotherapy project 'Dynarad' within the European Community has been to compare and grade treatment techniques that are currently applied or being developed at the participating institutions. Cervical cancer was selected as the tumour site on the grounds that the involved organs at risk, mainly the rectum and the bladder, are very close to the tumour and partly located inside the internal target volume. In this work, a solid phantom simulating the pelvic anatomy was used by institutions in Belgium, France, Greece, Holland, Italy, Sweden and the United Kingdom. The results were evaluated using both biological and physical criteria. The main purpose of this parallel evaluation is to test the value of biological and physical evaluations in comparing treatment techniques. It is demonstrated that the biological objective functions allow a much higher conformality and a more clinically relevant scoring of the outcome. Often external beam treatment techniques have to be combined with intracavitary therapy to give clinically acceptable results. However, recent developments can reduce or even eliminate this need by delivering more conformal dose distributions using intensity modulated external dose delivery. In these cases the reliability of the patient set-up procedure becomes critical for the effectiveness of the treatment
Original languageEnglish
Pages (from-to)2459-2481
JournalPhysics in Medicine and Biology
Volume45
Issue number9
DOIs
Publication statusPublished - 2000

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