TY - JOUR
T1 - Comparison of vaginal and transabdominal collection of amniotic fluid for fetal lung maturity tests
AU - Wijnberger, Lia D. E.
AU - de Kleine, Madelijn
AU - Voorbij, Hieronymus A. M.
AU - Arabin, Birgit
AU - Engel, Henk
AU - Bruinse, Hein W.
AU - Visser, Gerard H. A.
AU - Mol, Ben W. J.
PY - 2010
Y1 - 2010
N2 - Backgrounds. The lecithin/spingomyelin (L/S) ratio and lamellar body count (LBC) are two tests that can be used to estimate the probability of the occurrence of respiratory distress syndrome (RDS). Our objective was to compare the prognostic capacity of the L/S ratio and the LBC in the prediction of RDS from amniotic fluid that was obtained either transabdominally or vaginally. Methods. Consecutive women undergoing amniotic fluid sampling for determination of fetal lung maturity were included. In case the membranes were ruptured, amniotic fluid was obtained vaginally. Otherwise, amniotic fluid was obtained by transabdominal amniocentesis. In each specimen, an L/S ratio and a LBC were measured. The predictive capacity of specimens that were obtained vaginally and transabdominally were compared by calculating the area under the receiver-operating-characteristic curve (AUC) analysis. Results. In 260 patients amniotic fluid was collected transabominally, whereas in the other 67 patients there were ruptured membranes, and fluid was collected vaginally. RDS occurred in 25% of the patients without ruptured membranes, and in 34% of the patients with ruptured membranes. For the L/S ratio, the AUC was 0.56 (SE 0.09) for the vaginally collected specimens, and 0.93 (SE 0.02) in the specimens that were collected abdominally. For the LBC, the AUCs were 0.52 (SE 0.08) and 0.84 (SE 0.03), respectively. Conclusions. Fetal lung maturity tests that are performed in vaginally obtained specimens in patients with ruptured membranes are of no use in the prediction of RDS
AB - Backgrounds. The lecithin/spingomyelin (L/S) ratio and lamellar body count (LBC) are two tests that can be used to estimate the probability of the occurrence of respiratory distress syndrome (RDS). Our objective was to compare the prognostic capacity of the L/S ratio and the LBC in the prediction of RDS from amniotic fluid that was obtained either transabdominally or vaginally. Methods. Consecutive women undergoing amniotic fluid sampling for determination of fetal lung maturity were included. In case the membranes were ruptured, amniotic fluid was obtained vaginally. Otherwise, amniotic fluid was obtained by transabdominal amniocentesis. In each specimen, an L/S ratio and a LBC were measured. The predictive capacity of specimens that were obtained vaginally and transabdominally were compared by calculating the area under the receiver-operating-characteristic curve (AUC) analysis. Results. In 260 patients amniotic fluid was collected transabominally, whereas in the other 67 patients there were ruptured membranes, and fluid was collected vaginally. RDS occurred in 25% of the patients without ruptured membranes, and in 34% of the patients with ruptured membranes. For the L/S ratio, the AUC was 0.56 (SE 0.09) for the vaginally collected specimens, and 0.93 (SE 0.02) in the specimens that were collected abdominally. For the LBC, the AUCs were 0.52 (SE 0.08) and 0.84 (SE 0.03), respectively. Conclusions. Fetal lung maturity tests that are performed in vaginally obtained specimens in patients with ruptured membranes are of no use in the prediction of RDS
U2 - https://doi.org/10.3109/14767050903258704
DO - https://doi.org/10.3109/14767050903258704
M3 - Article
C2 - 20540655
SN - 1476-7058
VL - 23
SP - 613
EP - 616
JO - Journal of maternal-fetal & neonatal medicine
JF - Journal of maternal-fetal & neonatal medicine
IS - 7
ER -