TY - CHAP
T1 - Compartmental Modeling in Emission Tomography
AU - Lammertsma, Adriaan A.
PY - 2021/1/1
Y1 - 2021/1/1
N2 - This chapter provides an overview of the basic principles of compartmental modeling as it is being applied to the quantitative analysis of positron emission tomography (PET) studies. Measurement of blood flow (perfusion) is used as an example of a single tissue compartment model and receptor studies are discussed in relation to a two tissue compartment model. Emphasis is placed on the accurate measurement of both arterial whole blood and metabolite-corrected plasma input functions. Reference tissue models are introduced as a noninvasive tool to investigate neuroreceptor studies. Finally, parametric methods are introduced in which calculations are performed at a voxel level.
AB - This chapter provides an overview of the basic principles of compartmental modeling as it is being applied to the quantitative analysis of positron emission tomography (PET) studies. Measurement of blood flow (perfusion) is used as an example of a single tissue compartment model and receptor studies are discussed in relation to a two tissue compartment model. Emphasis is placed on the accurate measurement of both arterial whole blood and metabolite-corrected plasma input functions. Reference tissue models are introduced as a noninvasive tool to investigate neuroreceptor studies. Finally, parametric methods are introduced in which calculations are performed at a voxel level.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85158935848&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/36785730
U2 - https://doi.org/10.1007/978-3-319-93785-4_42
DO - https://doi.org/10.1007/978-3-319-93785-4_42
M3 - Chapter
C2 - 36785730
SN - 9783319937847
T3 - Handbook of Particle Detection and Imaging: Second Edition
SP - 1431
EP - 1450
BT - Handbook of Particle Detection and Imaging: Second Edition
PB - Springer International Publishing
ER -