TY - JOUR
T1 - Compensatory intestinal antibody response against pro-inflammatory microbiota after bariatric surgery
AU - Scheithauer, Torsten P. M.
AU - Davids, Mark
AU - Winkelmeijer, Maaike
AU - Verdoes, Xanthe
AU - Aydin, Ömrüm
AU - de Brauw, Maurits
AU - van de Laar, Arnold
AU - Meijnikman, Abraham S.
AU - Gerdes, Victor E. A.
AU - van Raalte, Daniël
AU - Herrema, Hilde
AU - Nieuwdorp, Max
N1 - Funding Information: This work was supported by the Diabetes Fonds [2015.81]; Diabetes Fonds [2019.82.004]; ZonMw [09150182010020]; H2020 Marie Skłodowska-Curie Actions [H2020-MSCA-IF-2015]. DHvR was supported by a fellowship of the Dutch Diabetes Research Foundation and the EU Marie Curie Program. The BARIA study is funded by the Novo Nordisk Foundation (NNF15OC0016798). The BARIA study is a Scandinavian‐Dutch collaboration. HH is supported by a Senior Fellowship of the Dutch Diabetes Research Foundation (2019.82.004). MN was supported by a ZONMW VIDI grant 2013 [016.146.327]. We thank Fredrik Bäckhed for his support. Funding Information: DHvR was supported by a fellowship of the Dutch Diabetes Research Foundation and the EU Marie Curie Program. The BARIA study is funded by the Novo Nordisk Foundation (NNF15OC0016798). The BARIA study is a Scandinavian‐Dutch collaboration. HH is supported by a Senior Fellowship of the Dutch Diabetes Research Foundation (2019.82.004). MN was supported by a ZONMW VIDI grant 2013 [016.146.327]. We thank Fredrik Bäckhed for his support. Publisher Copyright: © 2022 The Author(s). Published with license by Taylor & Francis Group, LLC.
PY - 2022/2/7
Y1 - 2022/2/7
N2 - Obesity and type 2 diabetes (T2D) are growing burdens for individuals and the health-care system. Bariatric surgery is an efficient, but drastic treatment to reduce body weight, normalize glucose values, and reduce low-grade inflammation. The gut microbiome, which is in part controlled by intestinal antibodies, such as IgA, is involved in the development of both conditions. Knowledge of the effect of bariatric surgery on systemic and intestinal antibody response is limited. Here, we determined the fecal antibody and gut microbiome response in 40 T2D and non-diabetic (ND) obese individuals that underwent bariatric surgery (N = 40). Body weight, fasting glucose concentrations and inflammatory parameters decreased after bariatric surgery, whereas pro-inflammatory bacterial species such as lipopolysaccharide (LPS), and flagellin increased in the feces. Simultaneously, concentrations of LPS- and flagellin-specific intestinal IgA levels increased with the majority of pro-inflammatory bacteria coated with IgA after surgery. Finally, serum antibodies decreased in both groups, along with a lower inflammatory tone. We conclude that intestinal rearrangement by bariatric surgery leads to expansion of typical pro-inflammatory bacteria, which may be compensated by an improved antibody response. Although further evidence and mechanistic insights are needed, we postulate that this apparent compensatory antibody response might help to reduce systemic inflammation by neutralizing intestinal immunogenic components and thereby enhance intestinal barrier function after bariatric surgery.
AB - Obesity and type 2 diabetes (T2D) are growing burdens for individuals and the health-care system. Bariatric surgery is an efficient, but drastic treatment to reduce body weight, normalize glucose values, and reduce low-grade inflammation. The gut microbiome, which is in part controlled by intestinal antibodies, such as IgA, is involved in the development of both conditions. Knowledge of the effect of bariatric surgery on systemic and intestinal antibody response is limited. Here, we determined the fecal antibody and gut microbiome response in 40 T2D and non-diabetic (ND) obese individuals that underwent bariatric surgery (N = 40). Body weight, fasting glucose concentrations and inflammatory parameters decreased after bariatric surgery, whereas pro-inflammatory bacterial species such as lipopolysaccharide (LPS), and flagellin increased in the feces. Simultaneously, concentrations of LPS- and flagellin-specific intestinal IgA levels increased with the majority of pro-inflammatory bacteria coated with IgA after surgery. Finally, serum antibodies decreased in both groups, along with a lower inflammatory tone. We conclude that intestinal rearrangement by bariatric surgery leads to expansion of typical pro-inflammatory bacteria, which may be compensated by an improved antibody response. Although further evidence and mechanistic insights are needed, we postulate that this apparent compensatory antibody response might help to reduce systemic inflammation by neutralizing intestinal immunogenic components and thereby enhance intestinal barrier function after bariatric surgery.
KW - Immunoglobulin
KW - bariatric surgery
KW - flagellin
KW - gut microbiome
KW - lipopolysaccharide
UR - http://www.scopus.com/inward/record.url?scp=85124268828&partnerID=8YFLogxK
U2 - https://doi.org/10.1080/19490976.2022.2031696
DO - https://doi.org/10.1080/19490976.2022.2031696
M3 - Article
C2 - 35130127
SN - 1949-0976
VL - 14
JO - Gut microbes
JF - Gut microbes
IS - 1
M1 - 2031696
ER -