Complete sequence analysis of the A*1103 allele

H. J. Tijssen, E. A. Sistermans, M. Van Den Beucken, P. Krausa, I. Joosten

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Here we report the full-length sequence of a novel A*11 variant. The variant was identified by ARMS-PCR and serology; the sequence was confirmed by cloning and subsequent sequencing. This variant, A*1103, found in a family of oriental origin, resembles the A*1101 sequence in exon 2 but differs in exon 3 with regard to codons 151 and 152. The polymorphism's result in two amino acid substitutions (one conserved (His->Arg) one introducing a negative charge (Ala->Glu)) located in the α2 helical region. The arginine at amino acid position 151 is rare amongst A-locus alleles and is besides A*1103 only observed in A*29 variants, the glutamine at amino acid position 152 is shared with A*0301, A*25, *26, *34 variants and the A*02 subtypes A*0203, *0213 and *0226. In fact, the amino acid motif comprising codons 151 and 152 is unique to A*1103 among A-locus alleles, but is common to C-locus alleles.

Original languageEnglish
Pages (from-to)68-70
Number of pages3
JournalTissue Antigens
Issue number1
Publication statusPublished - 2000


  • A*1103
  • HLA-A
  • Sequencing

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