Complex High-Risk Indicated Percutaneous Coronary Intervention With Prophylactic Use of the Impella CP Ventricular Assist Device

Deborah M F van den Buijs, Floris S van den Brink, Adriaan Wilgenhof, Carlo Zivelonghi, Niels Verouden, Paul Knaapen, Krischan D Sjauw, Paul Vermeersch, Alex Nap

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OBJECTIVES: Patients with complex coronary artery disease, concomitant cardiac disease, and multiple comorbidities are addressed as complex higher-risk indicated patients (CHIPs). Selecting a revascularization strategy in this population remains challenging. If coronary artery bypass grafting is deemed high risk or patients are considered inoperable, high-risk percutaneous coronary intervention (PCI) with the support of the Impella CP ventricular assist device (Abiomed) may be an attractive alternative.

METHODS: In this retrospective, multicenter study, we included consecutive patients undergoing Impella CP-facilitated complex high-risk PCI. All patients were discussed by the heart team and were declined for surgery. Additionally, periprocedural mechanical circulatory support was deemed necessary. We collected demographic, clinical, and procedural characteristics. Major adverse cardiac event (MACE) and mortality rates up to 30 days were evaluated.

RESULTS: A total of 27 patients (median age, 73 ± 9.7 years; 74.1% men) were included in our study. The median SYNTAX score was 32 (range, 8-57) and EuroSCORE was 7.25% (range, 1.33-49.66; ± 12.76%). Periprocedural hemodynamic instability was observed in 1 patient (3.7%). In-hospital combined with 30-day mortality was 7.4% (2/27). No repeat revascularization was necessary. MACE was observed in 10 patients (37.0%). Six patients (22.2%) had a major bleeding complication, of which 2 were related to Impella access site. Median Impella run time was 1.22 hours and there was no significant decrease in kidney function. Median admission time after PCI was 3 days (range, 1-23; ± 4.76).

CONCLUSIONS: The Impella CP system showed good feasibility and provided adequate hemodynamic support during high-risk PCI in this CHIP population.

Original languageEnglish
Pages (from-to)E665-E671
JournalThe Journal of invasive cardiology
Issue number9
Publication statusPublished - Sept 2022


  • Aged
  • Aged, 80 and over
  • Coronary Artery Bypass
  • Coronary Artery Disease/complications
  • Female
  • Heart-Assist Devices
  • Humans
  • Male
  • Middle Aged
  • Percutaneous Coronary Intervention
  • Retrospective Studies
  • Treatment Outcome

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