TY - JOUR
T1 - Compositional and Functional MRI of Skeletal Muscle
T2 - A Review
AU - Hooijmans, Melissa T.
AU - Schlaffke, Lara
AU - Bolsterlee, Bart
AU - Schlaeger, Sarah
AU - Marty, Benjamin
AU - Mazzoli, Valentina
N1 - Funding Information: This work was supported by National Institutes of Health (NIH) grant K99AG07173502, Australian National Health and Medical Research Council (NHMRC) grant APP1156394, and NWO Veni grant 18103. Publisher Copyright: © 2023 International Society for Magnetic Resonance in Medicine.
PY - 2023
Y1 - 2023
N2 - Due to its exceptional sensitivity to soft tissues, MRI has been extensively utilized to assess anatomical muscle parameters such as muscle volume and cross-sectional area. Quantitative Magnetic Resonance Imaging (qMRI) adds to the capabilities of MRI, by providing information on muscle composition such as fat content, water content, microstructure, hypertrophy, atrophy, as well as muscle architecture. In addition to compositional changes, qMRI can also be used to assess function for example by measuring muscle quality or through characterization of muscle deformation during passive lengthening/shortening and active contractions. The overall aim of this review is to provide an updated overview of qMRI techniques that can quantitatively evaluate muscle structure and composition, provide insights into the underlying biological basis of the qMRI signal, and illustrate how qMRI biomarkers of muscle health relate to function in healthy and diseased/injured muscles. While some applications still require systematic clinical validation, qMRI is now established as a comprehensive technique, that can be used to characterize a wide variety of structural and compositional changes in healthy and diseased skeletal muscle. Taken together, multiparametric muscle MRI holds great potential in the diagnosis and monitoring of muscle conditions in research and clinical applications. Evidence Level: 5. Technical Efficacy: Stage 2.
AB - Due to its exceptional sensitivity to soft tissues, MRI has been extensively utilized to assess anatomical muscle parameters such as muscle volume and cross-sectional area. Quantitative Magnetic Resonance Imaging (qMRI) adds to the capabilities of MRI, by providing information on muscle composition such as fat content, water content, microstructure, hypertrophy, atrophy, as well as muscle architecture. In addition to compositional changes, qMRI can also be used to assess function for example by measuring muscle quality or through characterization of muscle deformation during passive lengthening/shortening and active contractions. The overall aim of this review is to provide an updated overview of qMRI techniques that can quantitatively evaluate muscle structure and composition, provide insights into the underlying biological basis of the qMRI signal, and illustrate how qMRI biomarkers of muscle health relate to function in healthy and diseased/injured muscles. While some applications still require systematic clinical validation, qMRI is now established as a comprehensive technique, that can be used to characterize a wide variety of structural and compositional changes in healthy and diseased skeletal muscle. Taken together, multiparametric muscle MRI holds great potential in the diagnosis and monitoring of muscle conditions in research and clinical applications. Evidence Level: 5. Technical Efficacy: Stage 2.
KW - composition
KW - function
KW - qMRI
KW - skeletal muscle
UR - http://www.scopus.com/inward/record.url?scp=85176144321&partnerID=8YFLogxK
U2 - https://doi.org/10.1002/jmri.29091
DO - https://doi.org/10.1002/jmri.29091
M3 - Review article
C2 - 37929681
SN - 1053-1807
JO - Journal of magnetic resonance imaging
JF - Journal of magnetic resonance imaging
ER -