TY - JOUR
T1 - Computed tomographic airway morphology after targeted lung denervation treatment in COPD
AU - Hartman, Jorine E.
AU - Herth, Felix J. F.
AU - Shah, Pallav
AU - AIRFLOW-2 Study Group
AU - Pison, Christophe
AU - Valipour, Arschang
AU - Slebos, Dirk-Jan
AU - Abele, Christine
AU - Firlinger, Irene
AU - Kothakuzhakal, Kiran
AU - Duller, Marina
AU - Lamprecht, Bernd
AU - Kropfmueller, Roland
AU - Holzmann, Kornelia
AU - Rathmeier, Sandra
AU - Hubner, Ralf
AU - Erdmann, Leonore
AU - Temmesfeld-Wollbrück, Bettina
AU - Ruwwe Glösenkamp, Christoph
AU - Gesierich, Wolfgang
AU - Reichenberger, Frank
AU - Niehaus, Christa
AU - Herth, Felix
AU - Eberhardt, Ralf
AU - Gompelmann, Daniela
AU - Rump, Brigitte
AU - Darwiche, Kaid
AU - Eisenmann, Stephan
AU - Kaiser, Ulrike
AU - Schwarz, Birte
AU - Sampel, Ulrike
AU - Schumann, Christian
AU - Kaiser, Robert
AU - Schumann-Stoiber, Kathryn
AU - Skowasch, Dirk
AU - Ring, Sabine
AU - Briault, Amandine
AU - Arbib, Francois
AU - Jondot, Marie
AU - Perez, Thierry
AU - Fournier, Clement
AU - Matran, Regis
AU - Catto, Michele
AU - Bautin, Nathalie
AU - de Broucker, Virginie
AU - Willemin, Marie
AU - Prevotat, Anne
AU - Bonta, Peter
AU - Annema, Jouke
AU - van de Pol, Marianne
AU - Goorsenberg, Annika
N1 - Funding Information: The AIRFLOW-2 trial was funded by Nuvaira Inc, Minneapolis, MN, USA . The funding source had no involvement in this analysis or in the writing of this manuscript. Funding Information: The AIRFLOW-2 trial was funded by Nuvaira Inc, Minneapolis, MN, USA. The funding source had no involvement in this analysis or in the writing of this manuscript.We would like to thank the Dutch Foundation for Asthma Prevention (Noorderlijke CARA stichting) for the grant we received which allowed us to purchase the software used for this analysis. Publisher Copyright: © 2022 The Author(s)
PY - 2023/1/1
Y1 - 2023/1/1
N2 - This post-hoc analysis of the AIRFLOW-2 trial investigated the changes in airway CT-parameters after targeted lung denervation (TLD) and whether these changes are associated with treatment response. In the treatment group (n = 32), an improvement in air trapping was significantly associated with an improvement in residual volume (RV). Furthermore, improvements in Pi10 and airway lumen were significantly associated with an improvement in both RV and FEV1. Our results could suggest that when improving airway characteristics like decreasing airway wall thickness and increasing the airway lumen, this leads to less air trapping and an improvement in clinical outcomes.
AB - This post-hoc analysis of the AIRFLOW-2 trial investigated the changes in airway CT-parameters after targeted lung denervation (TLD) and whether these changes are associated with treatment response. In the treatment group (n = 32), an improvement in air trapping was significantly associated with an improvement in residual volume (RV). Furthermore, improvements in Pi10 and airway lumen were significantly associated with an improvement in both RV and FEV1. Our results could suggest that when improving airway characteristics like decreasing airway wall thickness and increasing the airway lumen, this leads to less air trapping and an improvement in clinical outcomes.
UR - http://www.scopus.com/inward/record.url?scp=85142827916&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.rmed.2022.107059
DO - https://doi.org/10.1016/j.rmed.2022.107059
M3 - Article
C2 - 36459953
SN - 0954-6111
VL - 206
JO - Respiratory Medicine
JF - Respiratory Medicine
M1 - 107059
ER -