Conformational switch of syntaxin-1 controls synaptic vesicle fusion

S.H. Gerber, J.C. Rah, X. Liu, H. de Wit, I. Dulubova, A.C. Meyer, J. Rizo, M. Arancillo, R.E. Hammer, M. Verhage, C. Rosenmund, T.C. Südhof

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224 Citations (Scopus)

Abstract

During synaptic vesicle fusion, the soluble N-ethylmaleimide-sensitive factor-attachment protein receptor (SNARE) protein syntaxin-1 exhibits two conformations that both bind to Munc18-1: a "closed" conformation outside the SNARE complex and an "open" conformation in the SNARE complex. Although SNARE complexes containing open syntaxin-1 and Munc18-1 are essential for exocytosis, the function of closed syntaxin-1 is unknown. We generated knockin/knockout mice that expressed only open syntaxin-1B. Syntaxin-1B
Original languageEnglish
Pages (from-to)1507-1510
JournalScience
Volume321
DOIs
Publication statusPublished - 2008

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