Congenital Cytomegalovirus Infection in the Absence of Maternal Cytomegalovirus-IgM Antibodies

Julia Gunkel, Bloeme J. Van Der Knoop, Joppe Nijman, Linda S. De Vries, Gwendolyn T.R. Manten, Peter G.J. Nikkels, Jean Luc Murk, Johanna I.P. De Vries, Tom F.W. Wolfs

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9 Citations (Scopus)


Background: Congenital cytomegalovirus (cCMV) infections are the most prevalent intrauterine infections worldwide and are the result of maternal primary or non-primary infections. Early maternal primary infections are thought to carry the highest risk of fetal developmental abnormalities as seen by ultrasound; however, non-primary infections may prove equally detrimental. Methods/Results: This case series presents 5 cases with fetal abnormalities detected in the second and third trimester, in which cCMV infection was ruled out due to negative maternal CMV-IgM. Discussion: This series highlights the possible pitfalls in serology interpretation and fetal diagnosis necessary for appropriate parental counseling. Once fetal abnormalities have been confirmed and cCMV is suspected, maternal CMV serostatus and fetal infection should be determined. Maternal CMV serology may be ambiguous; therefore, caution should be exercised when interpreting the results.

Original languageEnglish
Pages (from-to)144-149
Number of pages6
JournalFetal Diagnosis and Therapy
Issue number2
Publication statusPublished - 1 Aug 2017


  • Congenital infection
  • Cytomegalovirus
  • Fetal ultrasound abnormalities
  • Maternal non-primary infection
  • Maternal primary infection
  • Outcome

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