Consanguinity sans reproche

Leo P. Ten Kate, Hans Scheffer, Martina C. Cornel, Joan G. van Lookeren Campagne

Research output: Contribution to journalArticleAcademicpeer-review

15 Citations (Scopus)


In a family with two cystic fibrosis (CF) patients and consanguineous parents, DNA analysis showed that the CF in the children was not caused by homozygosity by descent, since two different mutations were involved. A formula is given for calculating the probability that parental consanguinity, if it exists, is causally related to the existence of an autosomal recessive disease in affected children.

Original languageEnglish
Pages (from-to)295-296
Number of pages2
JournalHuman genetics
Issue number3
Publication statusPublished - 1 Jan 1991

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