Constitutive CD27/CD70 interaction induces expansion of effector-type T cells and results in IFNgamma-mediated B cell depletion

R. Arens; K. Tesselaar; P. A. Baars; G. M. van Schijndel; J. Hendriks; S. T. Pals; P. Krimpenfort; J. Borst; M. H. van Oers; R. A. van Lier

doi:https://doi.org/10.1016/S1074-7613(01)00236-9

Constitutive CD27/CD70 interaction induces expansion of effector-type T cells and results in IFNgamma-mediated B cell depletion

R. Arens, K. Tesselaar, P. A. Baars, G. M. van Schijndel, J. Hendriks, S. T. Pals, P. Krimpenfort, J. Borst, M. H. van Oers, R. A. van Lier

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Abstract

The interaction between the TNF receptor family member CD27 and its ligand CD70 provides a costimulatory signal for T cell expansion. Normally, tightly regulated expression of CD70 ensures the transient availability of this costimulatory signal. Mice expressing constitutive CD70 on B cells had higher peripheral T cell numbers that showed increased differentiation toward effector-type T cells. B cell numbers in CD70 transgenic (TG) mice progressively decreased in primary and secondary lymphoid organs. This B cell depletion was caused by CD27-induced production of IFNgamma in T cells. We conclude that apart from its role in controlling the size of the activated T cell pool, CD27 ligation contributes to immunity by facilitating effector T cell differentiation

Original language	English
Pages (from-to)	801-812
Journal	Immunity
Volume	15
Issue number	5
DOIs	https://doi.org/10.1016/S1074-7613(01)00236-9
Publication status	Published - 2001

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https://doi.org/10.1016/S1074-7613(01)00236-9

Cite this

@article{30196e7638384d6a833cc53405d0a37b,

title = "Constitutive CD27/CD70 interaction induces expansion of effector-type T cells and results in IFNgamma-mediated B cell depletion",

abstract = "The interaction between the TNF receptor family member CD27 and its ligand CD70 provides a costimulatory signal for T cell expansion. Normally, tightly regulated expression of CD70 ensures the transient availability of this costimulatory signal. Mice expressing constitutive CD70 on B cells had higher peripheral T cell numbers that showed increased differentiation toward effector-type T cells. B cell numbers in CD70 transgenic (TG) mice progressively decreased in primary and secondary lymphoid organs. This B cell depletion was caused by CD27-induced production of IFNgamma in T cells. We conclude that apart from its role in controlling the size of the activated T cell pool, CD27 ligation contributes to immunity by facilitating effector T cell differentiation",

author = "R. Arens and K. Tesselaar and Baars, {P. A.} and {van Schijndel}, {G. M.} and J. Hendriks and Pals, {S. T.} and P. Krimpenfort and J. Borst and {van Oers}, {M. H.} and {van Lier}, {R. A.}",

year = "2001",

doi = "https://doi.org/10.1016/S1074-7613(01)00236-9",

language = "English",

volume = "15",

pages = "801--812",

journal = "Immunity",

issn = "1074-7613",

publisher = "Cell Press",

number = "5",

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TY - JOUR

T1 - Constitutive CD27/CD70 interaction induces expansion of effector-type T cells and results in IFNgamma-mediated B cell depletion

AU - Arens, R.

AU - Tesselaar, K.

AU - Baars, P. A.

AU - van Schijndel, G. M.

AU - Hendriks, J.

AU - Pals, S. T.

AU - Krimpenfort, P.

AU - Borst, J.

AU - van Oers, M. H.

AU - van Lier, R. A.

PY - 2001

Y1 - 2001

N2 - The interaction between the TNF receptor family member CD27 and its ligand CD70 provides a costimulatory signal for T cell expansion. Normally, tightly regulated expression of CD70 ensures the transient availability of this costimulatory signal. Mice expressing constitutive CD70 on B cells had higher peripheral T cell numbers that showed increased differentiation toward effector-type T cells. B cell numbers in CD70 transgenic (TG) mice progressively decreased in primary and secondary lymphoid organs. This B cell depletion was caused by CD27-induced production of IFNgamma in T cells. We conclude that apart from its role in controlling the size of the activated T cell pool, CD27 ligation contributes to immunity by facilitating effector T cell differentiation

AB - The interaction between the TNF receptor family member CD27 and its ligand CD70 provides a costimulatory signal for T cell expansion. Normally, tightly regulated expression of CD70 ensures the transient availability of this costimulatory signal. Mice expressing constitutive CD70 on B cells had higher peripheral T cell numbers that showed increased differentiation toward effector-type T cells. B cell numbers in CD70 transgenic (TG) mice progressively decreased in primary and secondary lymphoid organs. This B cell depletion was caused by CD27-induced production of IFNgamma in T cells. We conclude that apart from its role in controlling the size of the activated T cell pool, CD27 ligation contributes to immunity by facilitating effector T cell differentiation

U2 - https://doi.org/10.1016/S1074-7613(01)00236-9

DO - https://doi.org/10.1016/S1074-7613(01)00236-9

M3 - Article

C2 - 11728341

SN - 1074-7613

VL - 15

SP - 801

EP - 812

JO - Immunity

JF - Immunity

IS - 5

ER -