TY - JOUR
T1 - Construction of a Frailty Index as a Novel Health Measure in Systemic Lupus Erythematosus
AU - Legge, Alexandra
AU - Kirkland, Susan
AU - Rockwood, Kenneth
AU - Andreou, Pantelis
AU - Bae, Sang-Cheol
AU - Gordon, Caroline
AU - Romero-Diaz, Juanita
AU - Sanchez-Guerrero, Jorge
AU - Wallace, Daniel J.
AU - Bernatsky, Sasha
AU - Clarke, Ann E.
AU - Merrill, Joan T.
AU - Ginzler, Ellen M.
AU - Fortin, Paul
AU - Gladman, Dafna D.
AU - Urowitz, Murray B.
AU - Bruce, Ian N.
AU - Isenberg, David A.
AU - Rahman, Anisur
AU - Alarcón, Graciela S.
AU - Petri, Michelle
AU - Khamashta, Munther A.
AU - Dooley, M. A.
AU - Ramsey-Goldman, Rosalind
AU - Manzi, Susan
AU - Zoma, Asad A.
AU - Aranow, Cynthia
AU - Mackay, Meggan
AU - Ruiz-Irastorza, Guillermo
AU - Lim, S. Sam
AU - Inanc, Murat
AU - van Vollenhoven, Ronald F.
AU - Jonsen, Andreas
AU - Nived, Ola
AU - Ramos-Casals, Manuel
AU - Kamen, Diane L.
AU - Kalunian, Kenneth C.
AU - Jacobsen, Soren
AU - Peschken, Christine A.
AU - Askanase, Anca
AU - Hanly, John G.
PY - 2020
Y1 - 2020
N2 - OBJECTIVE: To construct a Frailty Index (FI) as a measure of vulnerability to adverse outcomes among patients with systemic lupus erythematosus (SLE), using data from the Systemic Lupus International Collaborating Clinics (SLICC) inception cohort. METHODS: The SLICC inception cohort consists of recently diagnosed patients with SLE followed annually with clinical and laboratory assessments. For this analysis, the baseline visit was defined as the first study visit at which sufficient information was available for construction of an FI. Following a standard procedure, variables from the SLICC database were evaluated as potential health deficits. Selected health deficits were then used to generate a SLICC-FI. The prevalence of frailty in the baseline dataset was evaluated using established cutpoints for FI values. RESULTS: The 1683 patients with SLE (92.1% of the overall cohort) eligible for inclusion in the baseline dataset were mostly female (89%) with mean (SD) age 35.7 (13.4) years and mean (SD) disease duration 18.8 (15.7) months at baseline. Of 222 variables, 48 met criteria for inclusion in the SLICC-FI. Mean (SD) SLICC-FI was 0.17 (0.08) with a range from 0 to 0.51. At baseline, 27.1% (95% CI 25.0-29.2) of patients were classified as frail, based on SLICC-FI values > 0.21. CONCLUSION: The SLICC inception cohort permits feasible construction of an FI for use in patients with SLE. Even in a relatively young cohort of patients with SLE, frailty was common. The SLICC-FI may be a useful tool for identifying patients with SLE who are most vulnerable to adverse outcomes, but validation of this index is required prior to its use.
AB - OBJECTIVE: To construct a Frailty Index (FI) as a measure of vulnerability to adverse outcomes among patients with systemic lupus erythematosus (SLE), using data from the Systemic Lupus International Collaborating Clinics (SLICC) inception cohort. METHODS: The SLICC inception cohort consists of recently diagnosed patients with SLE followed annually with clinical and laboratory assessments. For this analysis, the baseline visit was defined as the first study visit at which sufficient information was available for construction of an FI. Following a standard procedure, variables from the SLICC database were evaluated as potential health deficits. Selected health deficits were then used to generate a SLICC-FI. The prevalence of frailty in the baseline dataset was evaluated using established cutpoints for FI values. RESULTS: The 1683 patients with SLE (92.1% of the overall cohort) eligible for inclusion in the baseline dataset were mostly female (89%) with mean (SD) age 35.7 (13.4) years and mean (SD) disease duration 18.8 (15.7) months at baseline. Of 222 variables, 48 met criteria for inclusion in the SLICC-FI. Mean (SD) SLICC-FI was 0.17 (0.08) with a range from 0 to 0.51. At baseline, 27.1% (95% CI 25.0-29.2) of patients were classified as frail, based on SLICC-FI values > 0.21. CONCLUSION: The SLICC inception cohort permits feasible construction of an FI for use in patients with SLE. Even in a relatively young cohort of patients with SLE, frailty was common. The SLICC-FI may be a useful tool for identifying patients with SLE who are most vulnerable to adverse outcomes, but validation of this index is required prior to its use.
KW - Cohort studies
KW - Outcome assessment
KW - Systemic lupus erythematosus
UR - http://www.scopus.com/inward/record.url?scp=85077401794&partnerID=8YFLogxK
U2 - https://doi.org/10.3899/jrheum.181338
DO - https://doi.org/10.3899/jrheum.181338
M3 - Article
C2 - 30988130
SN - 0315-162X
VL - 47
SP - 72
EP - 81
JO - Journal of rheumatology
JF - Journal of rheumatology
IS - 1
ER -