Corpus Callosum Tissue Loss and Development of Motor and Global Cognitive Impairment: The LADIS Study

K.S. Frederiksen, E. Garde, A. Skimminge, F. Barkhof, P. Scheltens, E.C.W. van Straaten, F. Fazekas, H. Baezner, A. Verdelho, J.M. Ferro, T. Erkinjuntti, H. Jokinen, L.O. Wahlund, J. T. O'Brien, A.M. Basile, L. Pantoni, D. Inzitari, G. Waldemar

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Objective: To examine the impact of corpus callosum (CC) tissue loss on the development of global cognitive and motor impairment in the elderly. Methods: This study was based on the Leukoaraiosis and Disability (LADIS) study. Assessment of cognitive and motor functions and magnetic resonance imaging (MRI) were done at baseline and at a 3-year follow-up in nondemented elderly subjects. Results: 328 of 639 LADIS subjects had MRIs at baseline and at the 3-year follow-up, which allowed for assessment of CC. Logistic regression revealed differential tissue loss rates in posterior CC in subjects converting to dementia, compared to non-converters (p <0.05). Anterior and posterior CC tissue loss was significantly correlated with self-perceived memory impairment in nonconverters (p <0.05). CC tissue loss was also significantly associated with impaired single leg stance time (p <0.01). Conclusion: The present longitudinal study on CC supports the role of callosal tissue loss in the development of global cognitive as well as motor impairment. Copyright (C) 2012 S. Karger AG, Basel
Original languageEnglish
Pages (from-to)279-286
JournalDementia and geriatric cognitive disorders
Issue number4
Publication statusPublished - 2011

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