Corpus Callosum Tissue Loss and Development of Motor and Global Cognitive Impairment: The LADIS Study

K.S. Frederiksen; E. Garde; A. Skimminge; F. Barkhof; P. Scheltens; E.C.W. van Straaten; F. Fazekas; H. Baezner; A. Verdelho; J.M. Ferro; T. Erkinjuntti; H. Jokinen; L.O. Wahlund; J. T. O'Brien; A.M. Basile; L. Pantoni; D. Inzitari; G. Waldemar

doi:https://doi.org/10.1159/000334949

Corpus Callosum Tissue Loss and Development of Motor and Global Cognitive Impairment: The LADIS Study

K.S. Frederiksen, E. Garde, A. Skimminge, F. Barkhof, P. Scheltens, E.C.W. van Straaten, F. Fazekas, H. Baezner, A. Verdelho, J.M. Ferro, T. Erkinjuntti, H. Jokinen, L.O. Wahlund, J. T. O'Brien, A.M. Basile, L. Pantoni, D. Inzitari, G. Waldemar

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22 Citations (Scopus)

Abstract

Objective: To examine the impact of corpus callosum (CC) tissue loss on the development of global cognitive and motor impairment in the elderly. Methods: This study was based on the Leukoaraiosis and Disability (LADIS) study. Assessment of cognitive and motor functions and magnetic resonance imaging (MRI) were done at baseline and at a 3-year follow-up in nondemented elderly subjects. Results: 328 of 639 LADIS subjects had MRIs at baseline and at the 3-year follow-up, which allowed for assessment of CC. Logistic regression revealed differential tissue loss rates in posterior CC in subjects converting to dementia, compared to non-converters (p <0.05). Anterior and posterior CC tissue loss was significantly correlated with self-perceived memory impairment in nonconverters (p <0.05). CC tissue loss was also significantly associated with impaired single leg stance time (p <0.01). Conclusion: The present longitudinal study on CC supports the role of callosal tissue loss in the development of global cognitive as well as motor impairment. Copyright (C) 2012 S. Karger AG, Basel

Original language	English
Pages (from-to)	279-286
Journal	Dementia and geriatric cognitive disorders
Volume	32
Issue number	4
DOIs	https://doi.org/10.1159/000334949
Publication status	Published - 2011

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Frederiksen, K. S., Garde, E., Skimminge, A., Barkhof, F., Scheltens, P., van Straaten, E. C. W., Fazekas, F., Baezner, H., Verdelho, A., Ferro, J. M., Erkinjuntti, T., Jokinen, H., Wahlund, L. O., O'Brien, J. T., Basile, A. M., Pantoni, L., Inzitari, D., & Waldemar, G. (2011). Corpus Callosum Tissue Loss and Development of Motor and Global Cognitive Impairment: The LADIS Study. Dementia and geriatric cognitive disorders, 32(4), 279-286. https://doi.org/10.1159/000334949

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title = "Corpus Callosum Tissue Loss and Development of Motor and Global Cognitive Impairment: The LADIS Study",

abstract = "Objective: To examine the impact of corpus callosum (CC) tissue loss on the development of global cognitive and motor impairment in the elderly. Methods: This study was based on the Leukoaraiosis and Disability (LADIS) study. Assessment of cognitive and motor functions and magnetic resonance imaging (MRI) were done at baseline and at a 3-year follow-up in nondemented elderly subjects. Results: 328 of 639 LADIS subjects had MRIs at baseline and at the 3-year follow-up, which allowed for assessment of CC. Logistic regression revealed differential tissue loss rates in posterior CC in subjects converting to dementia, compared to non-converters (p <0.05). Anterior and posterior CC tissue loss was significantly correlated with self-perceived memory impairment in nonconverters (p <0.05). CC tissue loss was also significantly associated with impaired single leg stance time (p <0.01). Conclusion: The present longitudinal study on CC supports the role of callosal tissue loss in the development of global cognitive as well as motor impairment. Copyright (C) 2012 S. Karger AG, Basel",

author = "K.S. Frederiksen and E. Garde and A. Skimminge and F. Barkhof and P. Scheltens and {van Straaten}, E.C.W. and F. Fazekas and H. Baezner and A. Verdelho and J.M. Ferro and T. Erkinjuntti and H. Jokinen and L.O. Wahlund and O'Brien, {J. T.} and A.M. Basile and L. Pantoni and D. Inzitari and G. Waldemar",

year = "2011",

doi = "https://doi.org/10.1159/000334949",

language = "English",

volume = "32",

pages = "279--286",

journal = "Dementia and geriatric cognitive disorders",

issn = "1420-8008",

publisher = "S. Karger AG",

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Frederiksen, KS, Garde, E, Skimminge, A, Barkhof, F , Scheltens, P , van Straaten, ECW, Fazekas, F, Baezner, H, Verdelho, A, Ferro, JM, Erkinjuntti, T, Jokinen, H, Wahlund, LO, O'Brien, JT, Basile, AM, Pantoni, L, Inzitari, D & Waldemar, G 2011, 'Corpus Callosum Tissue Loss and Development of Motor and Global Cognitive Impairment: The LADIS Study', Dementia and geriatric cognitive disorders, vol. 32, no. 4, pp. 279-286. https://doi.org/10.1159/000334949

TY - JOUR

T1 - Corpus Callosum Tissue Loss and Development of Motor and Global Cognitive Impairment: The LADIS Study

AU - Frederiksen, K.S.

AU - Garde, E.

AU - Skimminge, A.

AU - Barkhof, F.

AU - Scheltens, P.

AU - van Straaten, E.C.W.

AU - Fazekas, F.

AU - Baezner, H.

AU - Verdelho, A.

AU - Ferro, J.M.

AU - Erkinjuntti, T.

AU - Jokinen, H.

AU - Wahlund, L.O.

AU - O'Brien, J. T.

AU - Basile, A.M.

AU - Pantoni, L.

AU - Inzitari, D.

AU - Waldemar, G.

PY - 2011

Y1 - 2011

N2 - Objective: To examine the impact of corpus callosum (CC) tissue loss on the development of global cognitive and motor impairment in the elderly. Methods: This study was based on the Leukoaraiosis and Disability (LADIS) study. Assessment of cognitive and motor functions and magnetic resonance imaging (MRI) were done at baseline and at a 3-year follow-up in nondemented elderly subjects. Results: 328 of 639 LADIS subjects had MRIs at baseline and at the 3-year follow-up, which allowed for assessment of CC. Logistic regression revealed differential tissue loss rates in posterior CC in subjects converting to dementia, compared to non-converters (p <0.05). Anterior and posterior CC tissue loss was significantly correlated with self-perceived memory impairment in nonconverters (p <0.05). CC tissue loss was also significantly associated with impaired single leg stance time (p <0.01). Conclusion: The present longitudinal study on CC supports the role of callosal tissue loss in the development of global cognitive as well as motor impairment. Copyright (C) 2012 S. Karger AG, Basel

AB - Objective: To examine the impact of corpus callosum (CC) tissue loss on the development of global cognitive and motor impairment in the elderly. Methods: This study was based on the Leukoaraiosis and Disability (LADIS) study. Assessment of cognitive and motor functions and magnetic resonance imaging (MRI) were done at baseline and at a 3-year follow-up in nondemented elderly subjects. Results: 328 of 639 LADIS subjects had MRIs at baseline and at the 3-year follow-up, which allowed for assessment of CC. Logistic regression revealed differential tissue loss rates in posterior CC in subjects converting to dementia, compared to non-converters (p <0.05). Anterior and posterior CC tissue loss was significantly correlated with self-perceived memory impairment in nonconverters (p <0.05). CC tissue loss was also significantly associated with impaired single leg stance time (p <0.01). Conclusion: The present longitudinal study on CC supports the role of callosal tissue loss in the development of global cognitive as well as motor impairment. Copyright (C) 2012 S. Karger AG, Basel

U2 - https://doi.org/10.1159/000334949

DO - https://doi.org/10.1159/000334949

M3 - Article

C2 - 22262017

SN - 1420-8008

VL - 32

SP - 279

EP - 286

JO - Dementia and geriatric cognitive disorders

JF - Dementia and geriatric cognitive disorders

IS - 4

ER -