TY - JOUR
T1 - Cortical Development Mediates Association of Prenatal Maternal Depressive Symptoms and Child Reward Sensitivity
T2 - A Longitudinal Study
AU - Wei, Dongtao
AU - Zhang, Han
AU - Broekman, Birit F.P.
AU - Chong, Yap Seng
AU - Shek, Lynette P.
AU - Yap, Fabian
AU - Tan, Kok Hian
AU - Gluckman, Peter D.
AU - Meaney, Michael J.
AU - Fortier, Marielle V.
AU - Qiu, Anqi
N1 - Funding Information: This work was supported by the Singapore National Research Foundation under its Translational and Clinical Research (TCR) Flagship Programme and administered by the Singapore Ministry of Health’s National Medical Research Council (NMRC), Singapore- NMRC/TCR/004-NUS/2008; NMRC/TCR/012-NUHS/2014. Additional funding is provided by Singapore Ministry of Education (Academic research fund tier 1; NUHSRO/2017/052/T1-SRP-Partnership/01); and NUS Institute of Data Science, Singapore. Publisher Copyright: © 2021 American Academy of Child and Adolescent Psychiatry Copyright: Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2022/3
Y1 - 2022/3
N2 - Objective: Maternal depression during pregnancy has long-term impacts on offspring. This study used neuroimaging and behavioral data from children aged 4 to 6 years and investigated whether prenatal maternal depressive symptoms (pre-MDS) associated with child cortical morphological development and subsequent reward-related behaviors in preschoolers. Method: Pre-MDS was measured using the Edinburgh Postnatal Depression Scale at 26 weeks of pregnancy. Children (n = 130) underwent structural magnetic resonance imaging (MRI) at both 4 and 6 years of age. Child sensitivity to reward and punishment was reported by mothers when children were 6 years of age. Linear mixed-effect models examined pre-MDS associations with child cortical thickness and surface area. Mediation analysis examined whether cortical development mediated associations between pre-MDS and child sensitivity to reward and punishment. Results: The 3-way interactions of pre-MDS, age, and sex on cortical thickness and surface area were not statistically significant. We found a significant interaction of pre-MDS with sex on the cortical surface area but not on thickness or their growth from 4 to 6 years, adjusting for ethnicity, socioeconomic status, baseline age, and postnatal MDS as covariates. Higher pre-MDS scores were associated with larger surface areas in the prefrontal cortex, superior temporal gyrus, and superior parietal lobe (SPL) in boys, whereas the opposite pattern was seen in girls. The SPL surface area mediated the relationship between pre-MDS and sensitivity to reward in girls. Conclusion: Prenatal maternal depression alters the cortical morphology of pre-schoolers in a sex-dependent manner.
AB - Objective: Maternal depression during pregnancy has long-term impacts on offspring. This study used neuroimaging and behavioral data from children aged 4 to 6 years and investigated whether prenatal maternal depressive symptoms (pre-MDS) associated with child cortical morphological development and subsequent reward-related behaviors in preschoolers. Method: Pre-MDS was measured using the Edinburgh Postnatal Depression Scale at 26 weeks of pregnancy. Children (n = 130) underwent structural magnetic resonance imaging (MRI) at both 4 and 6 years of age. Child sensitivity to reward and punishment was reported by mothers when children were 6 years of age. Linear mixed-effect models examined pre-MDS associations with child cortical thickness and surface area. Mediation analysis examined whether cortical development mediated associations between pre-MDS and child sensitivity to reward and punishment. Results: The 3-way interactions of pre-MDS, age, and sex on cortical thickness and surface area were not statistically significant. We found a significant interaction of pre-MDS with sex on the cortical surface area but not on thickness or their growth from 4 to 6 years, adjusting for ethnicity, socioeconomic status, baseline age, and postnatal MDS as covariates. Higher pre-MDS scores were associated with larger surface areas in the prefrontal cortex, superior temporal gyrus, and superior parietal lobe (SPL) in boys, whereas the opposite pattern was seen in girls. The SPL surface area mediated the relationship between pre-MDS and sensitivity to reward in girls. Conclusion: Prenatal maternal depression alters the cortical morphology of pre-schoolers in a sex-dependent manner.
KW - child behavior
KW - cortical development
KW - cortical morphology
KW - maternal depression during pregnancy
KW - structural MRI
UR - http://www.scopus.com/inward/record.url?scp=85109012594&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.jaac.2021.05.021
DO - https://doi.org/10.1016/j.jaac.2021.05.021
M3 - Article
C2 - 34146666
SN - 0890-8567
VL - 61
SP - 392
EP - 401
JO - Journal of the American Academy of Child and Adolescent Psychiatry
JF - Journal of the American Academy of Child and Adolescent Psychiatry
IS - 3
ER -