Course of minimal dementia and predictors of outcome

Pieter Jelle Visser, Frans R.J. Verhey, Jellemer Jolles, Cees Jonker

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Background: Previous studies have indicated that not all subjects who meet the CAMDEX criteria of 'minimal dementia' progress to dementia. In the present study, predictors of outcome in minimally demented subjects were tested. Methods: Forty-five subjects with minimal dementia who were participating in a population-based study were followed-up for on average 2.3 years. Variables tested as predictors of outcome were age, the apolipoprotein E (APOE) genotype, and the baseline scores on the MMSE, CAMCOG memory subscale, and fluency. Depression at baseline was tested as a predictor of reversible minimal dementia. Results: At follow-up, minimal dementia turned out to be reversible in 11 subjects (24%), and persistent in ten subjects (22%). Twenty-four subjects (53%) had become demented. Predictors of outcome in multivariate analyses were age, score on the CAMCOG memory subscale, and the APOE genotype. Depression was not associated with reversible minimal dementia. Conclusions: Subjects who meet the CAMDEX criteria of minimal dementia form a heterogenous group with respect to clinical outcome. Age, the score on the CAMCOG memory subscale, and the APOE genotype can improve predictive accuracy in these subjects.

Original languageEnglish
Pages (from-to)835-841
Number of pages7
JournalInternational journal of geriatric psychiatry
Issue number9
Publication statusPublished - 1 Sept 2002


  • Mild cognitive impairment
  • Minimal dementia
  • Population-based study
  • Prospective study

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