TY - JOUR
T1 - Course of pandemic influenza A(H1N1) 2009 virus infection in Dutch patients
AU - Friesema, Ingrid H. M.
AU - Meijer, Adam
AU - van Gageldonk-Lafeber, Arianne B.
AU - van der Lubben, Mariken
AU - van Beek, Janko
AU - Donker, Gé A.
AU - Prins, Jan M.
AU - de Jong, Menno D.
AU - Boskamp, Simone
AU - Isken, Leslie D.
AU - Koopmans, Marion P. G.
AU - van der Sande, Marianne A. B.
AU - AUTHOR GROUP
AU - van Asten, L.
AU - Baas, D.
AU - Beaujean, D.
AU - van Beek, J.
AU - van Binnendijk, R.
AU - van Boven, M.
AU - Coutinho, R.
AU - Dijkstra, F.
AU - Donker, T.
AU - Friesema, I. H. M.
AU - van Gageldonk-Lafeber, A. B.
AU - Heijningen, F.
AU - van der Hoek, W.
AU - Isken, L.
AU - van der Klis, F.
AU - van 't Klooster, T.
AU - Koopmans, M.
AU - Kretzschmar, M.
AU - van der Lubben, I. M.
AU - Mak, M.
AU - Meijer, A.
AU - Reimerink, J.
AU - Riesmeijer, R.
AU - van der Sande, M. A. B.
AU - van Steenbergen, J.
AU - Steens, A.
AU - Teunis, P.
AU - Timen, A.
AU - Vinck, L.
AU - Wallinga, J.
AU - Westerhof, A.
AU - Wielders, L.
AU - van den Wijngaard, C. C.
AU - Donker, G. A.
AU - Hooiveld, M.
AU - IJzermans, J.
AU - Schellevis, F.
AU - Verheij, R.
PY - 2012
Y1 - 2012
N2 - The clinical dynamics of influenza A(H1N1) 2009 infections in 61 laboratory-confirmed Dutch cases were examined. An episode lasted a median of 7 5 days of which 2 days included fever. Respiratory symptoms resolved slowly, while systemic symptoms peaked early in the episode and disappeared quickly. Severity of each symptom was rated highest in the first few days. Furthermore, diarrhoea was negatively associated with viral load, but not with faecal excretion of influenza virus. Cases with comorbidities appeared to have higher viral loads than the cases without, suggesting a less effective immune response. These results complement information obtained through traditional surveillance
AB - The clinical dynamics of influenza A(H1N1) 2009 infections in 61 laboratory-confirmed Dutch cases were examined. An episode lasted a median of 7 5 days of which 2 days included fever. Respiratory symptoms resolved slowly, while systemic symptoms peaked early in the episode and disappeared quickly. Severity of each symptom was rated highest in the first few days. Furthermore, diarrhoea was negatively associated with viral load, but not with faecal excretion of influenza virus. Cases with comorbidities appeared to have higher viral loads than the cases without, suggesting a less effective immune response. These results complement information obtained through traditional surveillance
U2 - https://doi.org/10.1111/j.1750-2659.2012.00347.x
DO - https://doi.org/10.1111/j.1750-2659.2012.00347.x
M3 - Article
C2 - 22372759
SN - 1750-2640
VL - 6
SP - e16-e20
JO - Influenza and other respiratory viruses
JF - Influenza and other respiratory viruses
IS - 3
ER -