CRISPR-Based Functional Genomics Studies Reveal Distinct and Overlapping Genes Mediating Resistance to Different Classes of Heterobifunctional Degraders of Oncoproteins: Implications for Novel Therapeutics across Diverse Neoplasias

Ryosuke Shirasaki; Sara Gandolfi; Ricardo De Matos Simoes; Geoffrey Matthews; Dennis Buckley; Olga Dashevsky; Sondra L. Downey-Kopyscinski; Huihui Tang; Michal Sheffer; Eugen Dhimolea; Brian Glassner; Megan Bariteau; Jeffrey Sorrell; Johanna B. Bruggenthies; Quinlan Sievers; Haley Poarch; Nicholas P. Kwiatkowski; Tinghu Zhang; Jacob Laubach; Robert L. Schlossman; Paul Richardson; Aedin Culhane; Richard W. J. Groen; Eric S. Fischer; Francisca Vazquez; Aviad Tsherniak; William C. Hahn; Joan Levy; Daniel Auclair; Jonathan D. Licht; Jonathan J. Keats; Lawrence H. Boise; Benjamin L. Ebert; James Bradner; Nathanae Gray; Constantine S. Mitsiades

doi:https://doi.org/10.1182/blood-2018-99-116232

CRISPR-Based Functional Genomics Studies Reveal Distinct and Overlapping Genes Mediating Resistance to Different Classes of Heterobifunctional Degraders of Oncoproteins: Implications for Novel Therapeutics across Diverse Neoplasias

Ryosuke Shirasaki, Sara Gandolfi, Ricardo De Matos Simoes, Geoffrey Matthews, Dennis Buckley, Olga Dashevsky, Sondra L. Downey-Kopyscinski, Huihui Tang, Michal Sheffer, Eugen Dhimolea, Brian Glassner, Megan Bariteau, Jeffrey Sorrell, Johanna B. Bruggenthies, Quinlan Sievers, Haley Poarch, Nicholas P. Kwiatkowski, Tinghu Zhang, Jacob Laubach, Robert L. SchlossmanPaul Richardson, Aedin Culhane, Richard W. J. Groen, Eric S. Fischer, Francisca Vazquez, Aviad Tsherniak, William C. Hahn, Joan Levy, Daniel Auclair, Jonathan D. Licht, Jonathan J. Keats, Lawrence H. Boise, Benjamin L. Ebert, James Bradner, Nathanae Gray, Constantine S. Mitsiades

Research output: Contribution to journal › Meeting Abstract › Academic

Original language	English
Journal	Blood
Volume	132
DOIs	https://doi.org/10.1182/blood-2018-99-116232
Publication status	Published - 29 Nov 2018

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https://doi.org/10.1182/blood-2018-99-116232

Cite this

Shirasaki, R., Gandolfi, S., Simoes, R. D. M., Matthews, G., Buckley, D., Dashevsky, O., Downey-Kopyscinski, S. L., Tang, H., Sheffer, M., Dhimolea, E., Glassner, B., Bariteau, M., Sorrell, J., Bruggenthies, J. B., Sievers, Q., Poarch, H., Kwiatkowski, N. P., Zhang, T., Laubach, J., ... Mitsiades, C. S. (2018). CRISPR-Based Functional Genomics Studies Reveal Distinct and Overlapping Genes Mediating Resistance to Different Classes of Heterobifunctional Degraders of Oncoproteins: Implications for Novel Therapeutics across Diverse Neoplasias. Blood, 132. https://doi.org/10.1182/blood-2018-99-116232

@article{eb1b1a84adc7499683a36e1061670545,

title = "CRISPR-Based Functional Genomics Studies Reveal Distinct and Overlapping Genes Mediating Resistance to Different Classes of Heterobifunctional Degraders of Oncoproteins: Implications for Novel Therapeutics across Diverse Neoplasias",

author = "Ryosuke Shirasaki and Sara Gandolfi and Simoes, {Ricardo De Matos} and Geoffrey Matthews and Dennis Buckley and Olga Dashevsky and Downey-Kopyscinski, {Sondra L.} and Huihui Tang and Michal Sheffer and Eugen Dhimolea and Brian Glassner and Megan Bariteau and Jeffrey Sorrell and Bruggenthies, {Johanna B.} and Quinlan Sievers and Haley Poarch and Kwiatkowski, {Nicholas P.} and Tinghu Zhang and Jacob Laubach and Schlossman, {Robert L.} and Paul Richardson and Aedin Culhane and Groen, {Richard W. J.} and Fischer, {Eric S.} and Francisca Vazquez and Aviad Tsherniak and Hahn, {William C.} and Joan Levy and Daniel Auclair and Licht, {Jonathan D.} and Keats, {Jonathan J.} and Boise, {Lawrence H.} and Ebert, {Benjamin L.} and James Bradner and Nathanae Gray and Mitsiades, {Constantine S.}",

year = "2018",

month = nov,

day = "29",

doi = "https://doi.org/10.1182/blood-2018-99-116232",

language = "English",

volume = "132",

journal = "Blood",

issn = "0006-4971",

publisher = "American Society of Hematology",

}

Shirasaki, R, Gandolfi, S, Simoes, RDM, Matthews, G, Buckley, D, Dashevsky, O, Downey-Kopyscinski, SL, Tang, H, Sheffer, M, Dhimolea, E, Glassner, B, Bariteau, M, Sorrell, J, Bruggenthies, JB, Sievers, Q, Poarch, H, Kwiatkowski, NP, Zhang, T, Laubach, J, Schlossman, RL, Richardson, P, Culhane, A, Groen, RWJ, Fischer, ES, Vazquez, F, Tsherniak, A, Hahn, WC, Levy, J, Auclair, D, Licht, JD, Keats, JJ, Boise, LH, Ebert, BL, Bradner, J, Gray, N & Mitsiades, CS 2018, 'CRISPR-Based Functional Genomics Studies Reveal Distinct and Overlapping Genes Mediating Resistance to Different Classes of Heterobifunctional Degraders of Oncoproteins: Implications for Novel Therapeutics across Diverse Neoplasias', Blood, vol. 132. https://doi.org/10.1182/blood-2018-99-116232

CRISPR-Based Functional Genomics Studies Reveal Distinct and Overlapping Genes Mediating Resistance to Different Classes of Heterobifunctional Degraders of Oncoproteins: Implications for Novel Therapeutics across Diverse Neoplasias. / Shirasaki, Ryosuke; Gandolfi, Sara; Simoes, Ricardo De Matos et al.
In: Blood, Vol. 132, 29.11.2018.

Research output: Contribution to journal › Meeting Abstract › Academic

TY - JOUR

T1 - CRISPR-Based Functional Genomics Studies Reveal Distinct and Overlapping Genes Mediating Resistance to Different Classes of Heterobifunctional Degraders of Oncoproteins: Implications for Novel Therapeutics across Diverse Neoplasias

AU - Shirasaki, Ryosuke

AU - Gandolfi, Sara

AU - Simoes, Ricardo De Matos

AU - Matthews, Geoffrey

AU - Buckley, Dennis

AU - Dashevsky, Olga

AU - Downey-Kopyscinski, Sondra L.

AU - Tang, Huihui

AU - Sheffer, Michal

AU - Dhimolea, Eugen

AU - Glassner, Brian

AU - Bariteau, Megan

AU - Sorrell, Jeffrey

AU - Bruggenthies, Johanna B.

AU - Sievers, Quinlan

AU - Poarch, Haley

AU - Kwiatkowski, Nicholas P.

AU - Zhang, Tinghu

AU - Laubach, Jacob

AU - Schlossman, Robert L.

AU - Richardson, Paul

AU - Culhane, Aedin

AU - Groen, Richard W. J.

AU - Fischer, Eric S.

AU - Vazquez, Francisca

AU - Tsherniak, Aviad

AU - Hahn, William C.

AU - Levy, Joan

AU - Auclair, Daniel

AU - Licht, Jonathan D.

AU - Keats, Jonathan J.

AU - Boise, Lawrence H.

AU - Ebert, Benjamin L.

AU - Bradner, James

AU - Gray, Nathanae

AU - Mitsiades, Constantine S.

PY - 2018/11/29

Y1 - 2018/11/29

U2 - https://doi.org/10.1182/blood-2018-99-116232

DO - https://doi.org/10.1182/blood-2018-99-116232

M3 - Meeting Abstract

SN - 0006-4971

VL - 132

JO - Blood

JF - Blood

ER -

Shirasaki R, Gandolfi S, Simoes RDM, Matthews G, Buckley D, Dashevsky O et al. CRISPR-Based Functional Genomics Studies Reveal Distinct and Overlapping Genes Mediating Resistance to Different Classes of Heterobifunctional Degraders of Oncoproteins: Implications for Novel Therapeutics across Diverse Neoplasias. Blood. 2018 Nov 29;132. doi: https://doi.org/10.1182/blood-2018-99-116232