Criteria voor geneesmiddelkeuze: Kwetsbare ouderen en antidepressiva

Translated title of the contribution: Criteria for drug selection: Frail elderly and antidepressants

Annette L. Van Ojik, Marieke Huisman-Baron, Lucia Van Der Veen, Paul A.F. Jansen, Jacobus R.B.J. Brouwers, Rob J. Van Marum, Eric N. Van Roon

Research output: Contribution to journalArticleProfessional

1 Citation (Scopus)


Pharmacotherapy in frail elderly is complicated and driven by multiple issues. As a result, physicians are faced with a complex task when prescribing to frail elderly patients. In this study, initiated by the Expertise Centre Pharmacotherapy for Older Persons (Ephor), a validated set of 23 criteria concerning effectiveness, safety, experience and convenience was developed to assist in the selection of the most appropriate drug within a drug class for the treatment of frail elderly patients. This method, using the 23 criteria, provides a complete overview of the relevant evidence for each individual drug. Evidence-based recommendations can be formulated for each individual drug within a drug class based on the pros and cons for frail elderly patients. Meanwhile, Ephor has formulated evidence-based recommendations for the antipsychotics, NSAIDs, ACE-inhibitors, opioids, hypnotics, anxiolytics, tricyclic antidepressants and second generation antidepressants. The complete reports are available at As an example, a summary of the reports of the tricyclic antidepressants and second generation antidepressants is given.

Translated title of the contributionCriteria for drug selection: Frail elderly and antidepressants
Original languageDutch
Pages (from-to)141-147
Number of pages7
JournalTijdschrift voor Ouderengeneeskunde
Issue number3
Publication statusPublished - 1 Jul 2012
Externally publishedYes

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