TY - JOUR
T1 - Cross-sectional comparison of the prevalence of age-associated comorbidities and their risk factors between HIV-infected and uninfected individuals: the AGEhIV cohort study
AU - Schouten, Judith
AU - Wit, Ferdinand W.
AU - Stolte, Ineke G.
AU - Kootstra, Neeltje A.
AU - van der Valk, Marc
AU - Geerlings, Suzanne E.
AU - Prins, Maria
AU - Reiss, Peter
AU - AUTHOR GROUP
AU - Kooij, K. W.
AU - van Zoest, R. A.
AU - Elsenga, B. C.
AU - Stolte, I. G.
AU - Martens, M.
AU - Moll, S.
AU - Berkel, J.
AU - Möller, L.
AU - Visser, G. R.
AU - Welling, C.
AU - Zaheri, S.
AU - Gras, L. A. J.
AU - van Leeuwen, E.
AU - Godfried, M. H.
AU - Goorhuis, A.
AU - van der Meer, J. T. M.
AU - Nellen, F. J. B.
AU - van der Poll, T.
AU - Prins, J. M.
AU - Wiersinga, W. J.
AU - Postema, P. G.
AU - Bisschop, P. H. L. T.
AU - Serlie, M. J. M.
AU - Dekker, E.
AU - de Rooij, S. E. J. A.
AU - Vogt, L.
AU - Portegies, P.
AU - Schmand, B. A.
AU - Geurtsen, G. J.
AU - van Eck-Smit, B. L. F.
AU - de Jong, M.
AU - Richel, D. J.
AU - Verbraak, F. D.
AU - Demirkaya, N.
AU - Ruhé, H. G.
AU - Nieuwkerk, P. T.
AU - van Steenwijk, R. P.
AU - Majoie, C. B. L. M.
AU - Caan, M. W. A.
AU - van Lunsen, H. W.
AU - van den Born, B. J. H.
AU - Stroes, E. S. G.
PY - 2014
Y1 - 2014
N2 - Human immunodeficiency virus (HIV)-infected individuals may be at increased risk of age-associated noncommunicable comorbidities (AANCCs). Cross-sectional analyses of AANCC prevalence (including cardiovascular, metabolic, pulmonary, renal, bone, and malignant disease) and risk factors in a prospective cohort study of HIV type 1-infected individuals and HIV-uninfected controls, who were aged ≥45 years and comparable regarding most lifestyle and demographic factors. HIV-infected participants (n = 540) had a significantly higher mean number of AANCCs than controls (n = 524) (1.3 [SD, 1.14] vs 1.0 [SD, 0.95]; P < .001), with significantly more HIV-infected participants having ≥1 AANCC (69.4% vs 61.8%; P = .009). Hypertension, myocardial infarction, peripheral arterial disease, and impaired renal function were significantly more prevalent among HIV-infected participants. Risk of AANCC by ordinal logistic regression was independently associated with age, smoking, positive family history for cardiovascular/metabolic disease, and higher waist-to-hip ratio, but also with HIV infection (odds ratio, 1.58 [95% confidence interval, 1.23-2.03]; P < .001). In those with HIV, longer exposure to CD4 counts <200 cells/µL, and, to a lesser extent, higher levels of high-sensitivity C-reactive protein and soluble CD14, and longer prior use of high-dose ritonavir (≥400 mg/24 hours) were each also associated with a higher risk of AANCCs. All AANCCs were numerically more prevalent, with peripheral arterial, cardiovascular disease, and impaired renal function significantly so, among HIV-infected participants compared with HIV-uninfected controls. Besides recognized cardiovascular risk factors, HIV infection and longer time spent with severe immunodeficiency increased the risk of a higher composite AANCC burden. There was a less pronounced contribution from residual inflammation, immune activation, and prior high-dose ritonavir use
AB - Human immunodeficiency virus (HIV)-infected individuals may be at increased risk of age-associated noncommunicable comorbidities (AANCCs). Cross-sectional analyses of AANCC prevalence (including cardiovascular, metabolic, pulmonary, renal, bone, and malignant disease) and risk factors in a prospective cohort study of HIV type 1-infected individuals and HIV-uninfected controls, who were aged ≥45 years and comparable regarding most lifestyle and demographic factors. HIV-infected participants (n = 540) had a significantly higher mean number of AANCCs than controls (n = 524) (1.3 [SD, 1.14] vs 1.0 [SD, 0.95]; P < .001), with significantly more HIV-infected participants having ≥1 AANCC (69.4% vs 61.8%; P = .009). Hypertension, myocardial infarction, peripheral arterial disease, and impaired renal function were significantly more prevalent among HIV-infected participants. Risk of AANCC by ordinal logistic regression was independently associated with age, smoking, positive family history for cardiovascular/metabolic disease, and higher waist-to-hip ratio, but also with HIV infection (odds ratio, 1.58 [95% confidence interval, 1.23-2.03]; P < .001). In those with HIV, longer exposure to CD4 counts <200 cells/µL, and, to a lesser extent, higher levels of high-sensitivity C-reactive protein and soluble CD14, and longer prior use of high-dose ritonavir (≥400 mg/24 hours) were each also associated with a higher risk of AANCCs. All AANCCs were numerically more prevalent, with peripheral arterial, cardiovascular disease, and impaired renal function significantly so, among HIV-infected participants compared with HIV-uninfected controls. Besides recognized cardiovascular risk factors, HIV infection and longer time spent with severe immunodeficiency increased the risk of a higher composite AANCC burden. There was a less pronounced contribution from residual inflammation, immune activation, and prior high-dose ritonavir use
U2 - https://doi.org/10.1093/cid/ciu701
DO - https://doi.org/10.1093/cid/ciu701
M3 - Article
C2 - 25182245
SN - 1058-4838
VL - 59
SP - 1787
EP - 1797
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
IS - 12
ER -