TY - JOUR
T1 - CSF biomarkers and medial temporal lobe atrophy predict dementia in mild cognitive impairment
AU - Bouwman, F. H.
AU - Schoonenboom, S. N.M.
AU - van der Flier, W. M.
AU - van Elk, E. J.
AU - Kok, A.
AU - Barkhof, F.
AU - Blankenstein, M. A.
AU - Scheltens, Ph
PY - 2007/7/1
Y1 - 2007/7/1
N2 - Objective: To study CSF biomarkers, beta-amyloid1-42 (Aβ1-42) and tau, and medial temporal lobe atrophy (MTA) on MRI in their ability to predict dementia in patients with mild cognitive impairment (MCI). Methods: Fifty-nine MCI patients (49% male, mean age 69 ± 8), follow-up 19 months, were included. Baseline CSF levels of Aβ1-42, tau and MTA-score were dichotomized. Results: Thirty-three (56%) of the MCI patients progressed to dementia, 30 of which had Alzheimer's disease. Lower CSF Aβ1-42 level, higher CSF-tau and higher MTA-scores at baseline were found in progressed patients. Cox proportional hazards models revealed that abnormal CSF Aβ1-42, CSF tau and MTA were significantly associated with dementia at follow-up (hazard ratio (95% confidence interval): 4.0 (1.3-12.1), 5.9 (1.6-21.7) and 2.1 (1.0-4.6)). A fourfold higher risk was found for patients with both abnormal CSF biomarkers and MTA compared to patients with either test abnormal. Ninety-four percent of patients with both abnormalities converted to dementia. Conclusions: These findings suggest an added value of CSF to MRI in the diagnostic work up of patients presenting at a memory clinic.
AB - Objective: To study CSF biomarkers, beta-amyloid1-42 (Aβ1-42) and tau, and medial temporal lobe atrophy (MTA) on MRI in their ability to predict dementia in patients with mild cognitive impairment (MCI). Methods: Fifty-nine MCI patients (49% male, mean age 69 ± 8), follow-up 19 months, were included. Baseline CSF levels of Aβ1-42, tau and MTA-score were dichotomized. Results: Thirty-three (56%) of the MCI patients progressed to dementia, 30 of which had Alzheimer's disease. Lower CSF Aβ1-42 level, higher CSF-tau and higher MTA-scores at baseline were found in progressed patients. Cox proportional hazards models revealed that abnormal CSF Aβ1-42, CSF tau and MTA were significantly associated with dementia at follow-up (hazard ratio (95% confidence interval): 4.0 (1.3-12.1), 5.9 (1.6-21.7) and 2.1 (1.0-4.6)). A fourfold higher risk was found for patients with both abnormal CSF biomarkers and MTA compared to patients with either test abnormal. Ninety-four percent of patients with both abnormalities converted to dementia. Conclusions: These findings suggest an added value of CSF to MRI in the diagnostic work up of patients presenting at a memory clinic.
KW - CSF
KW - MRI
KW - Mild cognitive impairment
UR - http://www.scopus.com/inward/record.url?scp=34247331828&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.neurobiolaging.2006.05.006
DO - https://doi.org/10.1016/j.neurobiolaging.2006.05.006
M3 - Article
C2 - 16782233
SN - 0197-4580
VL - 28
SP - 1070
EP - 1074
JO - Neurobiology of aging
JF - Neurobiology of aging
IS - 7
ER -