TY - JOUR
T1 - Curdlan-mediated regulation of human phagocyte-specific chitotriosidase
AU - van Eijk, Marco
AU - Voorn-Brouwer, Tineke
AU - Scheij, Saskia S.
AU - Verhoeven, Arthur J.
AU - Boot, Rolf G.
AU - Aerts, Johannes M. F. G.
PY - 2010
Y1 - 2010
N2 - Human phagocyte-specific chitotriosidase is part of innate immunity and shows anti-fungal activity towards chitin-containing fungi. We investigated the effect of stimulation of the C-type lectin receptor dectin-1 by beta-1,3-glucan (curdlan) on chitotriosidase expression and release by human phagocytes. We observed that curdlan triggers chitotriosidase release from human neutrophils. In addition, we show that curdlan impairs chitotriosidase induction in monocytes. Finally, curdlan temporarily induces chitotriosidase in enzyme-expressing monocyte-derived macrophages, followed by reduction of chitotriosidase expression after prolonged stimulation. These data on regulation of phagocyte-specific chitotriosidase following curdlan recognition support an important role of chitotriosidase in the elimination of chitin-containing pathogens. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved
AB - Human phagocyte-specific chitotriosidase is part of innate immunity and shows anti-fungal activity towards chitin-containing fungi. We investigated the effect of stimulation of the C-type lectin receptor dectin-1 by beta-1,3-glucan (curdlan) on chitotriosidase expression and release by human phagocytes. We observed that curdlan triggers chitotriosidase release from human neutrophils. In addition, we show that curdlan impairs chitotriosidase induction in monocytes. Finally, curdlan temporarily induces chitotriosidase in enzyme-expressing monocyte-derived macrophages, followed by reduction of chitotriosidase expression after prolonged stimulation. These data on regulation of phagocyte-specific chitotriosidase following curdlan recognition support an important role of chitotriosidase in the elimination of chitin-containing pathogens. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved
U2 - https://doi.org/10.1016/j.febslet.2010.06.001
DO - https://doi.org/10.1016/j.febslet.2010.06.001
M3 - Article
C2 - 20541547
SN - 0014-5793
VL - 584
SP - 3165
EP - 3169
JO - FEBS letters
JF - FEBS letters
IS - 14
ER -