TY - JOUR
T1 - Cutting Edge: Virus Selectively Primes Human Langerhans Cells for CD70 Expression Promoting CD8(+) T Cell Responses
AU - van der Aar, Angelic M. G.
AU - de Groot, Rosa
AU - Sanchez-Hernandez, Marta
AU - Taanman, Esther W. M.
AU - van Lier, René A. W.
AU - Teunissen, Marcel B. M.
AU - de Jong, Esther C.
AU - Kapsenberg, Martien L.
PY - 2011
Y1 - 2011
N2 - The two outermost compartments of skin are populated by different Ag-presenting dendritic cell types. Epidermal Langerhans cells (LCs) are evolutionarily adapted to the continuous presence of harmless skin commensals by the selective lack of cell surface TLRs that sense bacteria. In this article, we analyze the ability of LCs and dermal dendritic cells (DDCs) to respond to virus infection. Live virus and intracellular TLR3-agonist dsRNA commit LCs more effectively than DDCs to stimulate naive CD8(+) T cell expansion and their differentiation into effector cells. This potent CD8(+) T cell-promoting capacity of LCs is causally related to high levels of virus-induced CD70 expression but not to IL-12 production. These data suggest a remarkable specialization of LCs in the induction of pathogen class-specific adaptive immunity. Whereas LCs ignore bacteria, they are superior to DDCs to initiate effective CD70-mediated CD8(+) T cells in response to virus stimulation. The Journal of Immunology, 2011, 187: 3488-3492
AB - The two outermost compartments of skin are populated by different Ag-presenting dendritic cell types. Epidermal Langerhans cells (LCs) are evolutionarily adapted to the continuous presence of harmless skin commensals by the selective lack of cell surface TLRs that sense bacteria. In this article, we analyze the ability of LCs and dermal dendritic cells (DDCs) to respond to virus infection. Live virus and intracellular TLR3-agonist dsRNA commit LCs more effectively than DDCs to stimulate naive CD8(+) T cell expansion and their differentiation into effector cells. This potent CD8(+) T cell-promoting capacity of LCs is causally related to high levels of virus-induced CD70 expression but not to IL-12 production. These data suggest a remarkable specialization of LCs in the induction of pathogen class-specific adaptive immunity. Whereas LCs ignore bacteria, they are superior to DDCs to initiate effective CD70-mediated CD8(+) T cells in response to virus stimulation. The Journal of Immunology, 2011, 187: 3488-3492
U2 - https://doi.org/10.4049/jimmunol.1101105
DO - https://doi.org/10.4049/jimmunol.1101105
M3 - Article
C2 - 21880979
SN - 0022-1767
VL - 187
SP - 3488
EP - 3492
JO - Journal of immunology (Baltimore, Md.
JF - Journal of immunology (Baltimore, Md.
IS - 7
ER -